eLife: New imaging technology helps uncover pathological changes in the lungs of PATIENT patients with COVID19.

August 25, 2020 /--- In a recent study, physicists from the University of G?ttingen, together with pathologists from the University of Hanover Medical University, developed a 3D imaging technique that allows high-resolution 3D imaging of severely damaged lung tissue from Covid-19.
to study in depth the changes caused by coronavirus in the structure of the alveo and vein systems.
results were published in the journal elife.
In severe Covid-19 cases, the researchers observed significant changes in the vein system, inflammation, blood clots, and "transparent membranes" made up of proteins and dead cells deposited on the walls of the alba bubbles, which made gas exchange difficult.
with its new imaging methods, these changes can be seen for the first time in larger tissues without cutting and dyeing or damaging tissue as in traditional histology.
Professor Tim Salditt, lead author of the study at www.pixabay.com, said: "Using zoom fault scanning technology, large areas of lung tissue encumbered in wax can be scanned for detailed examination to find areas around inflammation, blood vessels or bronchial tubes.
X-rays go deep into tissue, scientists can understand the relationship between microstructures and the larger functional structure of organs, which is important for visualizing blood vessel trees up to the smallest capillaries," he said.
the authors foresee that this new X-ray technique will be an extension of traditional histology and histological pathology, dating back to the 19th century, when optical microscopes were only just available, allowing pathologists to shed light on the microscopic origins of many diseases.
even today, pathologists follow the same basic steps to prepare and study tissue: chemical fixation, slieration, staining, and microscopy.
this traditional approach is not enough if you need 3D images, or if you have to use a computer program to filter, digitize, or analyze large numbers of images.
(bioon.com) Source: New insights into tissue lung in COVID-19 disease Original source: Marina Eckermann et al, 3d virtual pathohistology of lung tissue from COVID-19 patients on phase contrast x-rayography x-rayography tom, eLife (2020). DOI: 10.7554/eLife.60408.