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Myc is a powerful oncogene and is associated with most solid tumors, but it is also a powerful driver of cell death.
Src is the first tumor gene to be recognized.
Drosophila has two SFKs, including Src42A and Src64B.
The research team at the Center for Dynamics Research (BDR) found that reducing the consumption of a specific protein can stop cancer cells from growing.
It is known that the carcinogenic process of fruit flies and mammals is the same.
Hiroshi Nishida et al, Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila, eLife (2021).
Hiroshi Nishida et al, Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila, eLife (2021).
The activation of a single oncogene in a cell is not enough to make it a cancer cell.
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Src activation can induce cell proliferation and death, leading to mild tissue overgrowth
Src activation can induce cell proliferation and death, leading to mild tissue overgrowth"How the oncogene promotes cell death and cell proliferation at the same time has been controversial.
The oncogene Src promotes cell death and cell proliferation at the same time through a special route.
Reducing the amount of methionine in the diet can control the occurrence of p38 tumors.
For tumors with high SFK activity, the treatment of methionine in the diet may have clinical benefits.
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