eLife: The molecular mechanism of mechanical force-sensitive ion channel NompC opening under pressure

On June 8, 2021, Song Chen's research group from the Center for Quantitative Biology and the Joint Center for Life Sciences of Peking University, School of Life Sciences, Fudan University, and Yan Zhiqiang's group from the Shenzhen Bay Laboratory jointly published the title " The Push-to-Open Mechanism of the Tethered Mechanosensitive Ion Channel NompC" research paper

NompC (No mechanoreceptor potential C) is an ion channel that can be activated by mechanical stimulation.

Based on the above cryo-electron microscope structure, Song Chen’s research group used all-atom molecular dynamics simulations to study the response of NompC ion channels to two basic types of external mechanical stimuli

This work further explored the specific gating process of channel opening when NompC is squeezed

Based on the above results, the author proposed a mechanical model of NompC ion channel opening under pressure

Wang Yang, a postdoctoral fellow at Peking University's Institute of Frontier Interdisciplinary Studies, and Guo Yifeng, a master's student in the School of Life Sciences, Fudan University, are the co-first authors of this article

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