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    Home > Active Ingredient News > Infection > EMI: Effects of pneumococcal conjugate vaccine supply on Streptococcus pneumoniae infection and genetic recombination in Zhejiang, China, 2009-2019

    EMI: Effects of pneumococcal conjugate vaccine supply on Streptococcus pneumoniae infection and genetic recombination in Zhejiang, China, 2009-2019

    • Last Update: 2022-03-02
    • Source: Internet
    • Author: User
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    Background and purpose: Pneumococcal pneumonia is one of the leading causes of death in children worldwide
    .


    Pneumococcal conjugate vaccine (PCV) is considered the most effective way to prevent pneumococcal disease (PD), but how the suspension of PCV vaccination affects the prevalence of PD or the genetic evolution of S.


    Pneumococcal pneumonia is one of the leading causes of death in children worldwide


    Infect

    Results: We found that both PD and pneumococcal genomic variation were affected by PCV disruption
    .


    The proportion of vaccine-type pneumococcal LRTIs (VT-LRTIs) among all LRTI cases (~70%) declined to ~30% in late PCV7 and rebounded to ~70% after PCV7 failure in April 2015 (p=0.


    Table 1 Distribution of pathogenic and colonizing pneumococcal isolates
    .

    Table 1 Distribution of pathogenic and colonizing pneumococcal isolates
    .


    Fig.
    1 Serotype distribution of pathogenic pneumococci in different age groups
    .

    Fig.
    1 Serotype distribution of pathogenic pneumococci in different age groups
    .


    Figure 2 The proportion of vaccine-type pneumococcal-associated lower respiratory tract infection (VT-LRTI) and its correlation with PCV coverage

    Figure 2 The proportion of vaccine-type pneumococcal-associated lower respiratory tract infection (VT-LRTI) and its correlation with PCV coverage

    Figure 3 Phylogenetic tree and recombination events of pneumococcal isolates from children under 5 years of age
    .

    Figure 3 Phylogenetic tree and recombination events of pneumococcal isolates from children under 5 years of age
    .


    Figure 4 Recombination frequency (r/m) and number (re) of pneumococcal isolates from children under 5 years of age
    .

    Figure 4 Recombination frequency (r/m) and number (re) of pneumococcal isolates from children under 5 years of age
    .


    Conclusions: Our study shows for the first time that VT-LRTI fluctuates with the disruption of vaccine supply in China and leads to a decrease in the frequency of vaccine type recombination
    .


    Promoting an ongoing national vaccination program and strengthening molecular epidemiological surveillance of S.


    Our study shows for the first time that VT-LRTI fluctuates with the disruption of vaccine supply in China and leads to a decrease in the frequency of vaccine type recombination


    Streptococcus pneumoniaeEffect of pneumococcal conjugate vaccine availability on infections and genetic recombination in Zhejiang, China from 2009 to 2019Leave a comment here
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