Enantioseparations of Primary Amino Compounds by High-Performance Liquid Chromatography Using Chiral Crown Ether-Based Chiral Stationary Phase
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Last Update: 2020-12-09
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Source: Internet
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Author: User
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Liquid chromatographic resolution of racemic compounds containing a primary amino group has been known to be most successfulwhen chiral crown ether-based chiral stationary phases (CSPs) are used. Among various crown ether-based CSPs, the stationaryphase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel has been successfully appliedin the resolution of various racemic compounds containing primary amino groups. In this chapter, the preparation of the CSPbased on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel and examples for the applicationto the enantioseparation of racemic compounds including α-amino acids, cyclic amines, amino alcohols, and chiral drugs aredescribed.
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