Endoscopy: Should patients with severe acute necrotitis use pancreatic tube stents preventively?

Common pancreatic tube damage in patients with acute necrotitis (ANP).
in this study, we tested the feasibility and safety of preventive pancreatic tube stents (PPDS) in ANP and compared PPDS to conservative therapy, the results of which were published online in Endoscopy.
researchers looked forward to the inclusion of patients (aged 18-75) who were diagnosed with ANP between February 2011 and July 2015.
patients were randomly treated with PPDS or conservative treatment at two level III centers.
PPDS as soon as possible after randomization.
results, concerns about accidental infections of pancreatic necrotasia in the PPDS group prompted researchers to conduct an interim analysis that confirmed a high risk increase.
, the trial was terminated early for ethical reasons.
of the 11 patients in the PPDS group, all patients with successful pancreatic tube replacement (5/5,100%) developed infection, while only 3 of the 13 patients in the conservative treatment group (23.1%) developed infection (P-0.01).
analysis showed that the success rate of pancreatic tube intage was 63.6%, the success rate of pancreatic tube stent placement was 45.5%, and the success rate of placement bracket bridge necrotization was 18.2%.
intitation and stent implants failed due to heterointestinal edema and stenosis of the pancreas.
, the results suggest that PPDS in ANP is associated with an unacceptable risk of high pancreatic necrotasia infection.
addition, the operation is technically challenging due to heterointestinal edema and stenosis of the pancreatic tube.
.