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    Home > Active Ingredient News > Drugs Articles > Endotoxin testing is required from 1 kg of injection-grade mannitol

    Endotoxin testing is required from 1 kg of injection-grade mannitol

    • Last Update: 2022-10-02
    • Source: Internet
    • Author: User
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    Injection-grade mannitol 1kg is ordered from endotoxin detection Mannitol is a good diuretic in medicine, reducing intracranial pressure, intraocular pressure and treating kidney drugs, dehydration drugs, sugar substitutes, and is also used as an excipient for tablets and a diluent of solids and liquids
    .

    As a hypertonic antihypertensive drug, mannitol injection (Injectio Mannitou) is a drug commonly used in clinical rescue, especially for the rescue of brain diseases, and has the characteristics
    of rapid antihypertensive efficacy required by drugs that reduce intracranial pressure.

    After mannitol enters the body, it can increase the osmolality of plasma, dehydrate the tissue, reduce intracranial pressure and intraocular pressure, after filtration from the glomerulus, it is not easy to be reabsorbed by the renal tubules, increase the osmolality of urine, bring out a large amount of water and dehydration, for head trauma, brain tumor, edema caused by hypoxia of brain tissue, edema caused by large-scale burns, ascites glaucoma
    caused by renal failure.

    It can also prevent and treat early acute renal insufficiency
    .

    As an excipient for tablets, mannitol has no moisture absorption, fast drying, good chemical stability, and has the characteristics of refreshing and granulogenic properties, and is used in most tablets such as anticancer drugs, antibacterials, antihistamines and vitamins
    .

    In addition, it is also used for chewable tablets such as decanting drugs and mouth coolants
    .

    Although mannitol can be absorbed by the human gastrointestinal tract, it is not accumulated
    in the body.

    After being absorbed, one part is metabolized in the body and the other part is excreted from the urine; Mannitol because of the heat absorption when dissolved, there is a sweet taste, there is a comfortable feeling for the mouth, so it is more widely used in the manufacture of chewable tablets such as decanting drugs and cooling agents in the mouth, and its granular type is specially used as an excipient
    for direct tableting.

    In the food field, the product has the least water absorption in sugar and sugar alcohol, and has a refreshing sweetness, which is used for anti-sticking of maltose, chewing gum, rice cakes and other foods, as well as as anti-stick powder
    for general pastries.

    Dibromomannitol
    can be prepared by hydrobromic acid reaction.

    It can also be used as a sweetener with low calorific value and low sugar such as food for diabetic patients and bodybuilding food
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