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    Home > Active Ingredient News > Drugs Articles > Energy Storage 2020 Pharmacopeia Series , rapid method conversion, helping pharmaceutical QC laboratory to improve efficiency

    Energy Storage 2020 Pharmacopeia Series , rapid method conversion, helping pharmaceutical QC laboratory to improve efficiency

    • Last Update: 2020-07-15
    • Source: Internet
    • Author: User
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    storage 2020 Pharmacopeia series , quick method conversion, help the pharmaceutical QC laboratory to improve efficiency
    pay attention to us, moredry goodsandsurprise good giftafter years of development, ultra-efficient liquid chromatography UHPLC technology, because it can get higher column efficiency and faster analysis speed, and in most cases can replace conventional HPLC methods, has been within a certain range of popularityHowever, the HPLC method is still used in most of the pharmaceutical industry's QC for QUALITY control due to the lack of accepted method conversion rulesThe general principles of liquid chromatography in the 2020 edition of the Chinese Pharmacopoeia finally give specific provisions for the adjustment of chromatography parametersreference to the new pharmacopeia guidelines, laboratory analysts can convert conventional HPLC methods to UHPLC methodsthe new version of the Pharmacopoeia 0512 general rule "high-efficiency liquid chromatography" provides that:"
    if the use of small particle size (about 2 sm) filler and small internal diameter (about 2.1mm) column or surface porous filler to improve separation or shorten the analysis time, the performance of the infusion pump, sample volume, detection pool volume and system volume dying must be matched if necessary, chromatography conditions must be appropriately adjusted"
    for the new version of the guidelines, the variety of the body of the specified chromatography conditions (parameters), in addition to filler types, flow phase components, detector types may not be changed, the rest such as the column diameter and length, filler particle size, flow phase velocity, flow phase component proportion, column temperature, sample quantity, detector sensitivity, etc., can be appropriately adjustedis critical for analysts to make rapid and efficient method conversionsa dedicated method conversion tool to easily generate target methodThermofei can provide a special method conversion tool for chromatography methods, can help you do the drug code-related rapid conversion gradient method,for the method conversion after the color column specifications, flow rate, sample volume, in the method conversion software left input original column specifications and gradient conditions, on the right side of the software input new column specifications, other conditions system will automatically generate for you, very convenient(click to see the larger picture)With the above gadgets, method conversion is no longer difficult, let's take a look at the actual case!Example onethe co-use of the Vanquish Coreand the nuclear shell-type Accucore column, supporting the Conversion of hPLC method into the UHPLC method
    (click to view the large image)column is the core of liquid phase separation and is the key to method conversionThe nuclear shell filler Accucore series of columnszuiis characterized by low anti-pressure, high column effect, from the above example, running time from75minto23.7min, greatly improving the analysis speed, while the anti-pressure is the conventional high-efficiency liquid chromatography acceptable range The HPLC instrument in the laboratory achieves the efficiency of the UHPLC instrument example II Vanquish Flex UHPLC and Acclaim column combination - strong combination, improve efficiency (click to see large picture) The series of ultra-efficient liquid chromatography column, high carbon load, effectively improve compound retention, improve separation at the same time, 2.2 m particle size in the same type of color column low back pressure, to meet more instrument requirements Combined with the Vanquish Flex's ultra-efficient liquid phase, you can achieve faster analysis under optimized conditions example three Vanquish Core the UHPLC Pharmacopoeia method conversion that supports gradients, speed and temperature changes - Super-flexible (click to see large picture) new Vanquish Core liquid phase system pressure-resistant 700bar, using the nuclear shell filler (Accucore series) column, according to the pharmacopeia principle conversion
    of the Ubemmexi UC (click to see the larger picture) The analysis time was reduced by nearly , the solvent consumption was reduced by 74% , and the enterprise saved significant efficiency!!! Example four The Codecsicore pharmacopeia conversion of the liquid phase support equivalents - polar zhi efficiency (click to see the big picture) the new Vanquish Core liquid phase system is pressure-resistant 700bar, using a series of ultra-efficient liquid chromatography columns, the multi-sau tea-alkali UHPLC method converted according to the pharmacopeia principle
    but the high pressure
    of 500, example five Vanquish Core double gradient analysis of red grain formula particles - left and right open bow, HPLC and UHPLC simultaneously (click to view the large picture) as shown in the flow map, Vanquish Core liquid matching with a double-pin double-valve double-flow automatic sampler, can do two different sets of application experiments at the same time, without any cross-contamination of the flow, completely independent, can also share a column It's the perfect choice for high efficiency and low cost (click to see the larger picture) After converting to the UHPLC method according to the pharmacopeia principle, the pressure is only 500 bar , and the parameter indicators meet the requirements of the public notice, and the analysis efficiency is improved
    by 300% , and the solvent cost is reduced by 87.5% The original do a needle into the time, equivalent to the method after the conversion of 4 needles into the sample, significant efficiency rapid method conversion can help pharmaceutical QC laboratory customers optimize their analytical methods and improve instrument efficiency in an all-round way , Thermofei can provide "comprehensive, efficient, compliant" solutions that create a holistic solution for the pharmaceutical industry that is the core of compliance data management and supported by innovation and technology, and leads to more efficient pharmaceutical industry development processes if you need to cooperate in reprinting this article, please leave a message at the end of the article scan the QR code below to get Aymer's Industry-wide solution, or follow the "ThermoFei Chromatography and Mass Spectrometry China" public hao for more information and
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