echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Enhancing the effect of cancer immunotherapy, activating p53 is expected to turn "cold" tumors into "hot" tumors

    Enhancing the effect of cancer immunotherapy, activating p53 is expected to turn "cold" tumors into "hot" tumors

    • Last Update: 2021-08-05
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    p53 is one of the most interesting targets for cancer therapy development, because more than 50% of cancer patients carry mutations in the TP53 gene encoding p53 protein


    A recent study published in Cancer Discovery recently revealed the new functions of p53.


    In cells, the function of p53 is inhibited by the naturally expressed MDM2 protein.


    To their surprise, activation of p53 can lead to the expression of endogenous retroviral (ERV) sequences in the cell genome


    Usually, an important role of p53 is to inhibit the expression of ERV sequences, but in this study, activation of p53 stimulated the expression of certain ERV sequences


    Further studies have found that the expression of ERV sequence triggers the antiviral response of human cells, leading to an increase in the level of interferon with antiviral ability


    ▲P53 activated by drugs can stimulate antiviral interferon response, increase T cell infiltration, and promote the efficacy of immune checkpoint inhibitors (picture source: reference [2])

    These results show that there is a synergistic effect between drugs that block MDM2 and cancer immunotherapy, which is worthy of further exploration


    Aprea Therapeutics, a company co-founded by Professor Selivanova, is already developing a p53 activator


    Note: The original text has been deleted

    Reference materials:

    [1] New cancer findings can give wider access to immunotherapy.


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.