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    Home > Active Ingredient News > Study of Nervous System > Epilepsia: Anti-epileptic drugs increase the risk of major cardiovascular events

    Epilepsia: Anti-epileptic drugs increase the risk of major cardiovascular events

    • Last Update: 2021-06-01
    • Source: Internet
    • Author: User
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    medsci.


    medsci.


    Using anonymous, routinely collected health care data from Wales, UK, a retrospective matched cohort study (2003-2017) was conducted on adult epilepsy patients taking antiepileptic drugs.


    medsci.


    Subject recruitment flowchart

    Subject recruitment flowchart

    A total of 10241 cases (average age 49.


    A total of 10241 cases (average age 49.


    The figure above shows the unadjusted and adjusted time-event models of the case group and the control group.


    Diagnosing diabetic myocardial infarction

    The figure above shows the unadjusted and adjusted time-event survival curves of enzyme-induced antiepileptic drugs (EIAED) and non-enzyme-induced antiepileptic drugs (NEIAED) treatment groups.


    Compared with the control group, the risk of major cardiovascular events in cases increased (adjusted hazard ratio = 1.


    Compared with the control group, epilepsy patients taking antiepileptic drugs have an increased risk of major cardiovascular events .


    The increased risk of major cardiovascular events in epilepsy patients taking antiepileptic drugs has increased the risk of major cardiovascular events in epilepsy patients taking antiepileptic drugs, which emphasizes the importance of cardiovascular risk management in the clinical care of epilepsy patients.


    wiley.


    wiley.
    com/action/showCitFormats?doi=10.
    1111%2Fepi.
    16930" target="_blank" rel="noopener">Lee-Lane, E.
    , Torabi, F.
    , Lacey, A.
    , Fonferko-Shadrach, B.
    , Harris, D.
    , Akbari, A.
    , Lyons, RA, Rees, MI, Sawhney, I.
    , Halcox, J .
    , Powell, R.
    and Pickrell, WO (2021), Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events.
    Epilepsia.
    https://doi.
    org/10.
    1111/epi.
    16930

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