Erythropoietin and Engineered Innate Repair Activators
Last Update: 2021-02-28
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Erythropoietin (EPO) is a pleiotropic type I cytokine that has been identified as a major endogenous tissue protective molecule. In response to injury, EPO and a distinct receptor are expressed with a characteristic temporal and spatial expression pattern. Together, these serve to limit injury and to initiate repair. Administration of EPO in the setting of injury has been shownto be beneficial in a multitude of preclinical models. However, translation into the clinic has been hampered by EPO’s adverseeffects, including promotion of thrombosis. Recently, engineered molecules based on EPO’s structure–activity relationshipshave been developed that are devoid of hematopoietic effects. These compounds are promising candidates for treatment of awide variety of acute and chronic diseases.
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