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The types of veterinary drugs in animal-derived foods are increasing year by year.
With so many types and items of veterinary drug testing, the same sample often needs to be tested repeatedly, which not only prolongs the testing time, increases the loss of equipment, but also increases the testing cost
.
In addition, if you want to buy all standard veterinary drugs, you need to spend a lot of money and costs
At present, the gas chromatography mass spectrometry standard database has been widely established and successfully applied to pesticides and other environmental pollutants, providing a reliable basis for the qualitative detection of pesticide residues
.
Among them, the National Institute of Science and Technology Mass Spectrometry Library (NIST) is the most widely used, such as the determination of 143 pesticides in fish, the determination of 160 pesticides and 25 persistent organic pollutants in grapes and wine, and 16 organochlorine pesticides in vegetables.
The work of this chapter collects mass spectrometry information of quasi-molecular ions and fragment ions for commonly used veterinary drugs, and summarizes the obtained mass spectra information to form an accurate mass database, including the English name of the compound, molecular formula, retention time, ionization mode and different energies Fragment ion mass spectra
.
On this basis, according to the fragment ions of the drug, the mass spectrometry fragmentation law of this kind of drug is discussed
22.
2.
1 Reagents and materials
Table 22-1 Experimental materials
22.
2.
Preparation of single standard stock solution: the purity of all veterinary drug standard substances is ≥95% (Dr.
Ehrenstorfer GmbH); weigh about 10mg of standard substance in a 10mL volumetric flask with analytical balance, dilute methanol to the mark, and add 1 to individual insoluble standard substances ~ 2 mL dimethyl sulfoxide (DMSO); all standard products are stored in the refrigerator, protected from light at 4°C
.
Reference solution preparation: For the real-time calibration of the instrument, the method uses the reference solution provided by Agilent.
Pipette 1.
0 mL Purine and 1.
0 mL HP-0921 respectively, and dilute with acetonitrile : water (95+5, v/v) solution To 1 L, add the prepared solution to the reference solution bottle for use in the measurement process of the instrument
.
Tuning solution preparation: For the comprehensive calibration of the accurate quality of the instrument, the method uses the standard solution provided by Agilent, but the preparation of the ESI and EST tuning solutions is different.
The specific preparation method is shown in Table 22-2
.
Table 22-2 Tuning solution preparation table
22.
2.
The main instruments required for this experiment are shown in Table 22-3
Table 22-3 Experimental equipment