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Euho Pharmaceutical's YH002 combined with YH001 clinical study completed the first patient dosing

 Last Update: 2022-04-30
 Source: Internet
 Author: User

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tumor microenvironment

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On March 8, Euho Pharma, a wholly-owned subsidiary of Biositu, announced an international multi-center (MRCT) Phase I clinical study of its YH002 (OX40 monoclonal antibody) combined with its YH001 (CTLA-4 monoclonal antibody) (No.

This study is an open-label, phase I dose escalation study of YH002 mAb combined with YH001 mAb in patients with advanced solid tumors

Prior to this, Yoho Pharma had completed the single-dose escalation studies of YH001 and YH002, respectively, and the results showed that YH001 and YH002 had good tolerability and safety

About YH002

YH002 is a recombinant humanized IgG1 monoclonal antibody that specifically targets human tumor necrosis factor receptor superfamily member 4 (TNFRSF4, OX40), thereby inducing pleiotropic downstream anticancer activity

About YH001

YH001 is an anti-CTLA-4 monoclonal antibody that enhances the body's own immune response against tumor cells by enhancing the removal of regulatory T cells (Treg) in the tumor microenvironment, thereby achieving the purpose of treating various tumors

(Original abridged)

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