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Long-term sequelae may occur after SARS-CoV-2 infection
.
A study published in Eur Heart J, an authoritative journal in the cardiovascular field, aims to comprehensively assess the organ-specificity of individuals following mild to moderate SARS-CoV-2 infection compared with controls in the general population.
Infected blood vessels
Within a median of 9.
6 months after the first positive SARS-CoV-2 test, 443 non-hospitalized patients were examined and 1328 controls from the German population cohort were matched for age, sex, and education
.
The researchers assessed the status of the lungs, heart, blood vessels, kidneys, and nervous system, as well as patient-related outcomes
.
We used body plethysmography to record total lung volume (regression coefficient -3.
Cardiac assessment in patients after SARS-CoV-2 infection showed measures of left ventricular (transthoracic echocardiography, regression coefficient of left ventricular ejection fraction -0.
93, adjusted P=0.
015) and right ventricular function compared with matched controls Values were slightly lower, and cardiac biomarker concentrations were higher (1.
14 for high-sensitivity troponin, 1.
41 for the N-terminus of B-type natriuretic peptide precursor, adjusted P≤0.
01), but cardiac magnetic resonance imaging results were not significantly different
.
After SARS-CoV-2 infection, the ultrasound-incompressible femoral vein showed a significantly higher frequency of deep vein thrombosis (odds ratio, 2.
thrombus
CONCLUSIONS : Subjects recovering from mild to moderate SARS-CoV-2 infection showed signs of subclinical multiorgan lesions associated with lung, heart, thrombosis, and renal function without structural brain damage, Signs of neurocognitive or quality of life
impairment .
Appropriate screening can guide further patient management
Subjects recovering from mild to moderate SARS-CoV-2 infection showed signs of subclinical multiorgan lesions associated with lung, cardiac, thrombosis, and renal function without structural brain damage, neurocognitive or Signs of impaired quality of life
Original source:
Elina Larissa Petersen, et al.
Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
