Eur Heart J: Obesity and weight loss are negatively associated with prediabetes and type 2 diabetes mortality and cardiovascular outcomes

The association between weight and weight changes in patients with diabetes (DM) and mortality and cardiovascular (CV) outcomes is not clearIn a recent study published in the authoritative journal Eur Heart J, the cardiovascular field, researchers aimed to assess the relationship between known cardiovascular risk factors and weight, weight changes, and patient outcomes in patients with type 2 DM or prediabetes12,521 participants from the ORIGIN trial were classified according to BMI: low body weight (BMI) 22 kg/m2), normal (22-24.9), overweight (25-29.9), 1-3 obesity (30-34.9, 35-39.9, or 40 kg/m2)Outcome variables include total and CV mortality and comprehensive outcomes of CV death, non-fatal stroke or myocardial infarction plus blood transport reconstruction, or hospitalization for heart failurefollow-up time is 6.2 years (quartile range 5.8-6.7 years)After multivariate adjustment, the total mortality rate of overweight and mildly obese patients (HR) was 0.80 compared to patients with normal BMI (95% confidence interval (CI) was 0.69-0.91); 0.95), P 0.01) and CV mortality (overweight patienthr 0.79 (0.66-0.94); Obesity of any severity is not associated with a higher mortality rateLow body weight was associated with an increase in mortality rates of 1.28 (1.02-1.61) and cardiovascular mortality hr of 1.34 (1.01-1.79), And P 0.05Weight loss for two years was associated with a higher risk of mortality (HR 1.32 (1.18-1.46), P.0001) and CV mortality (HR 1.18 (1.02-1.35)) compared to patients withnobishIn turn, weight gain has nothing to do with any adverse outcomesit was not as likely that obesity in patients with Prediabetes had a higher mortality rate or poor CV outcomesPatients with overweight and moderate obesity (BMI 25-35 kg/m2) had the lowest risk of deathWeight loss is an independent risk factor for increased mortality compared to the absence of weight loss