Eur Heart J: The role of vitamin D deficiency in cardiovascular disease risk

Low vitamin D status associated with higher heart blood vessels (CVD) risk-related diseases
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Although most existing linear Mendelian randomization (MR) studies have reported no correlation between vitamin D and CVD risk, the non-linear effect between them cannot be ruled out

Vitamin D blood vessels

Recently, a research article was published in Eur Heart J, an authoritative journal in the cardiovascular field.
The purpose of the researchers is to apply a nonlinear MR design to explore the relationship between serum 25-hydroxyvitamin D[25(OH)D] concentration and CVD risk.
Associated
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The non-linear MR analysis of the study was conducted in the British Biobank and involved 44,519 CVD cases and 251,269 controls
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Blood pressure (BP) and cardiac imaging-derived phenotypes were listed as secondary outcomes

The researchers also estimated the potential effect of reducing the incidence of CVD as a result of correcting the low vitamin D status
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There is an L-shaped association between the genetically predicted serum 25(OH)D level and the CVD risk (non-linear P=0.

This shows that vitamin D deficiency will increase the risk of cardiovascular disease
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This non-linear Mendelian random analysis supports the existence of an L-shaped association between serum 25-hydroxyvitamin D concentration and CVD risk, which indicates that in terms of cardiovascular health, improving vitamin D status has benefits for individuals who are deficient

Vitamin D deficiency increases the risk of cardiovascular disease

Original source:

Ang Zhou,et al.

Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk in this message