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Eur J Cancer: The effect of enzalutamide in mCRPC patients in the elderly is better than that of abiraterone acetate

 Last Update: 2021-06-28
 Source: Internet
 Author: User

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Metastatic castration-resistant prostate cancer (mCRPC) disproportionately affects the elderly

This study aims to compare the clinical efficacy and tolerability of AA and enzalutamide in mCRPC patients 80 years and older

This is a retrospective propensity-weighted comparative cohort study that recruited mCRPC patients over 80 years of age who were treated with first-line AA or enzalutamide

A) The time from the start of treatment to the progression of PSA; B) The time before any progression; C) The time before treatment failure; D) Overall survival rate

A total of 278 patients were enrolled, of which 153 were treated with AA and 125 were treated with enzalutamide

Enzalutamide treatment is associated with a higher PSA remission rate and TTP , but not related to TTPP.

Enzalutamide is associated with a higher PSA response rate and longer time to progression Enzalutamide is associated with a higher PSA response rate and longer time to progression

Original source:

Soleimani Maryam,Zou Kevin,Sunderland Katherine et al.

Effectiveness of first-line abiraterone versus enzalutamide among patients ≥80 years of age with metastatic castration-resistant prostate cancer: A retrospective propensity score-weighted comparative cohort study

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