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Eur J Cancer: Thinking carefully, terrifying!

 Last Update: 2021-09-10
 Source: Internet
 Author: User

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In the past 20 years, about a proton pump inhibitor (PPI) is causing digestive argue that the tumor continues

Digestion

This study is a systematic review and meta-analysis, using the Bradford Hill criteria of causality comprehensive assessment of the PPI to digest the impact tract cancer risk

Digestion

The researchers searched the Medline, Embase, and Web of Science databases for observational studies published before January 15, 2021

PPI use andCorrelation of gastric cancer (A), esophageal cancer (B), colorectal cancer (C) and pancreatic cancer (D) risk

PPI use andCorrelation of gastric cancer (A), esophageal cancer (B), colorectal cancer (C) and pancreatic cancer (D) riskGastric cancer colorectal cancer pancreatic cancer

A total of 32 studies were screened, containing 4,355,254 subjects

The use of PPI is associated with an increased overall risk of gastrointestinal cancer.

The relationship between PPI use reaching a limited dose or prolonged duration and the risk of gastrointestinal cancer

The correlation between PPI use and gastrointestinal cancer is more pronounced in the population with the lowest PPI exposure

In summary, the use of PPI is associated with an increased risk of some gastrointestinal cancers .

The use of PPI is associated with an increased risk of gastrointestinal cancer .

Original source:

Zeng Ruijie,Cheng Yunjiu,Luo Dongling et al.

Comprehensive analyis of proton pump inhibitors and risk of digestive tract cancers

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