Proton pump inhibitors (PPIs) in divided doses can inhibit gastric acid secretion for 24 hours more effectively than the once-daily (qd) dose
Rabeprazole 5 mg qd is used to prevent gastric damage caused by aspirin, but it is not clear whether rabeprazole 5 mg twice a day (bid) can more effectively inhibit acid secretion
Recently, researchers compared the acid suppression effects of rabeprazole 10 mg qd and 5 mg bid in healthy volunteers with different alleles of CYP2C19.
The results of the study have been published in Eur J Clin Pharmaco
The study included 12 Helicobacter pylori-negative healthy volunteers (CYP2C19 genotypes: extensive metabolizers (EM) (n = 6) and poor metabolizers (PM) (n = 6)) who received three treatments under a randomized crossover design Plan 7 days: Rabeprazole 5 mg qd (5 mg QD), 10 mg qd (10 mg QD) and 5 mg bid (5 mg BID)
The pH value was monitored for 24 hours before the test and on the 7th day of each protocol
The results showed that the median pH (4.
9)) and (4.
5)) between the 10 mg QD and 5 mg BID regimens or the percentage time of pH ≥ 4 (50.
8%) ) And 56.
9%)) have no significant difference
The median pH of CYP2C19 PMs and the percentage time of pH≥4 were significantly higher than that of EMs
With 5 mg BID, there was no significant difference in the percentage time of pH ≥ 4 during the day and night, but 10 mg QD showed a significant difference
In summary, the results of the study show that compared with rabeprazole 10 mg qd, regardless of the status of the CYP2C19 genotype, rabeprazole 5 mg bid does not show an advantage in acid suppression
Masaki Murata, Mitsushige Sugimoto.
Effect of a rabeprazole half-dose twice daily on acid inhibition in patients with different CYP2C19 alleles .
Eur J Clin Pharmacol.
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