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    Home > Active Ingredient News > Digestive System Information > Eur J Clin Pharmacol: In patients with different CYP2C19 alleles, the effect of half-dose rabeprazole twice a day on acid suppression

    Eur J Clin Pharmacol: In patients with different CYP2C19 alleles, the effect of half-dose rabeprazole twice a day on acid suppression

    • Last Update: 2021-07-27
    • Source: Internet
    • Author: User
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    Proton pump inhibitors (PPIs) in divided doses can inhibit gastric acid secretion for 24 hours more effectively than the once-daily (qd) dose
    .
    Rabeprazole 5 mg qd is used to
    prevent gastric damage caused by aspirin, but it is not clear whether rabeprazole 5 mg twice a day (bid) can more effectively inhibit acid secretion
    .
    Recently, researchers compared the acid suppression effects of rabeprazole 10 mg qd and 5 mg bid in healthy volunteers with different alleles of CYP2C19.
    The results of the study have been published in Eur J Clin Pharmaco

    .

    prevention

    The study included 12 Helicobacter pylori-negative healthy volunteers (CYP2C19 genotypes: extensive metabolizers (EM) (n = 6) and poor metabolizers (PM) (n = 6)) who received three treatments under a randomized crossover design Plan 7 days: Rabeprazole 5 mg qd (5 mg QD), 10 mg qd (10 mg QD) and 5 mg bid (5 mg BID)
    .
    The pH value was monitored for 24 hours before the test and on the 7th day of each protocol

    .

     

    The results showed that the median pH (4.
    0 (1.
    9-5.
    9)) and (4.
    4 (2.
    1-6.
    5)) between the 10 mg QD and 5 mg BID regimens or the percentage time of pH ≥ 4 (50.
    7% (11.
    9-86.
    8%) ) And 56.
    8% (19.
    3-83.
    9%)) have no significant difference

    .
    The median pH of CYP2C19 PMs and the percentage time of pH≥4 were significantly higher than that of EMs

    .
    With 5 mg BID, there was no significant difference in the percentage time of pH ≥ 4 during the day and night, but 10 mg QD showed a significant difference

    .

    In summary, the results of the study show that compared with rabeprazole 10 mg qd, regardless of the status of the CYP2C19 genotype, rabeprazole 5 mg bid does not show an advantage in acid suppression
    .

     

    Original source:

     

    Masaki Murata, Mitsushige Sugimoto.
    Effect of a rabeprazole half-dose twice daily on acid inhibition in patients with different CYP2C19 alleles .
    Eur J Clin Pharmacol.
    2020 Sep;76(9):1253-1261.
    doi: 10.
    1007/s00228-020- 02917-w.
     

    Effect of a rabeprazole half-dose twice daily on acid inhibition in patients with different CYP2C19 alleles

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