Eur J Clin Pharmacol: In patients with different CYP2C19 alleles, the effect of half-dose rabeprazole twice a day on acid suppression

Proton pump inhibitors (PPIs) in divided doses can inhibit gastric acid secretion for 24 hours more effectively than the once-daily (qd) dose
.

The study included 12 Helicobacter pylori-negative healthy volunteers (CYP2C19 genotypes: extensive metabolizers (EM) (n = 6) and poor metabolizers (PM) (n = 6)) who received three treatments under a randomized crossover design Plan 7 days: Rabeprazole 5 mg qd (5 mg QD), 10 mg qd (10 mg QD) and 5 mg bid (5 mg BID)
.

The results showed that the median pH (4.
0 (1.
9-5.
9)) and (4.
4 (2.
1-6.
5)) between the 10 mg QD and 5 mg BID regimens or the percentage time of pH ≥ 4 (50.
7% (11.
9-86.
8%) ) And 56.
8% (19.
3-83.
9%)) have no significant difference
.

In summary, the results of the study show that compared with rabeprazole 10 mg qd, regardless of the status of the CYP2C19 genotype, rabeprazole 5 mg bid does not show an advantage in acid suppression

Original source:

Masaki Murata, Mitsushige Sugimoto.