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Eur J Endocrinol: Metformin may reduce the risk of colon polyps in patients with acromegaly!

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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30-40% of patients with acromegaly will develop colon polyps, leading to an increased risk of colon cancer .

This study aimed to evaluate the incidence of colon polyps before and after metformin treatment in patients with acromegaly, and to explore its potential protective effects.

Research Process

This is an exploratory cross-sectional study conducted at two tertiary referral centers in Italy.

Screening

Polyp histological classification

The overall prevalence of colon polyps is 36%.

multi-factor analysis

Multivariate analysis showed that colon polyps were significantly negatively correlated with metformin intake (OR 0.

Colon polyps are significantly negatively correlated with metformin intake (OR 0.

Metformin may have a certain protective effect on the occurrence and development of colon polyps in patients with acromegaly.

Original source:

Albertelli M, Nazzari E, Dotto A et al.

org/10.
1530/EJE-20-0795" target="_blank" rel="noopener">Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study in this message

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