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Eur J Endocrinol: Prenatal use of dexamethasone for classical 21-hydroxylase deficiency in a European population

 Last Update: 2022-04-20
 Source: Internet
 Author: User

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Background: Androgen excess in girls with congenital adrenal hyperplasia (CAH) results in variable degrees of virilization of the external genitalia

Androgen excess in girls with congenital adrenal hyperplasia (CAH) results in variable degrees of virilization of the external genitalia

This is an ethical dilemma because currently unaffected fetuses receive unnecessary treatment during the first trimester of fetal life

And most importantly, there is insufficient evidence for the safety of the fetus undergoing treatment

Third, so far, there is little data on maternal safety

So far, little data on maternal safety

OBJECTIVE: The aim of this study was to reflect current international perceptions of Pdex and practice across Europe at CAH, and to highlight the importance of longitudinal follow-up of treated cases and prospective clinical trials investigating different aspects of the therapy

Methods: A questionnaire with 17 questions was designed and distributed to collect quantitative and qualitative data

RESULTS: Pdex treatment is currently offered in 36 % of surveyed centres

Figure 1

Table 1

This study revealed high international variability and variability in the use of Pdex treatment across Europe

Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe

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