echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Infection > Eur Respir J: Anti-TB treatment, is the larger the dose of Lyphin, the better?

    Eur Respir J: Anti-TB treatment, is the larger the dose of Lyphin, the better?

    • Last Update: 2021-02-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    A growing body of data suggests that larger doses of lysolpin are more effective and can also shorten the duration of anti-TB treatment.
    study assessed the safety, tolerance, pharmacogenetics, and early sterilization activity (EBA) on days 7 and 14 to increase the dose of lysolpin.
    recently published in the European Respiratory Journal, the latest study, "Increased bactericidal activity but dose-limiting intolerability at 50 mg.kg rifampicin," reported the results of the final cohort of the PANACEA HIGHRIF1 study, an incremental dose study for untreated adult tuyang tuberculosis patients.
    In a continuous queue, the patient received a daily dose of 40 or 50 mg/kg of lyphopine (day 1-7), supplemented by standard doses of isoniazid, pyridine and ethyl butanol during the 8-14 day period.
    in the 40 mg/kg group (n=15), 13 patients had a total of 36 adverse events (AEs) during a single treatment period, resulting in a treatment interruption.
    in the 50 mg/kg group (n-17), all patients experienced adverse reactions during a single treatment period, with a total of 93 cases and 11 patients withdrawing or stopping the study.
    most of the AEs are mild to moderate, toned and safety-independent, with gastrointestinal diseases, itching, high biliary erythroidemia and jaundice.
    compared to 40 mg/kg, the geometric average AUC0-24h at 50 mg/kg in Lifuping increased significantly, and the exposure peak increased exponentally at 571 mg/L.h (range 320-995) vs 387 mg/L.h (201-847).
    non-protein binding exposure levels after 50 mg/kg were comparable to 30 mg/kg at lower doses.
    exposure was associated with bililin concentration.
    EBA increased significantly with the increase in dose, with the highest dose of 50 mg/kg: EBA on the 14th day was -0.427 logCFU/ml days.
    , although the dose of Lyphin at 50 mg/kg has a stronger sterilization effect, but its tolerance is not good.
    40 mg/kg, Lyphin is well-to-do and is therefore selected as the evaluated dose for the IIC phase shortening treatment trial.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.