-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
A growing body of data suggests that larger doses of lysolpin are more effective and can also shorten the duration of anti-TB treatment.
study assessed the safety, tolerance, pharmacogenetics, and early sterilization activity (EBA) on days 7 and 14 to increase the dose of lysolpin.
recently published in the European Respiratory Journal, the latest study, "Increased bactericidal activity but dose-limiting intolerability at 50 mg.kg rifampicin," reported the results of the final cohort of the PANACEA HIGHRIF1 study, an incremental dose study for untreated adult tuyang tuberculosis patients.
In a continuous queue, the patient received a daily dose of 40 or 50 mg/kg of lyphopine (day 1-7), supplemented by standard doses of isoniazid, pyridine and ethyl butanol during the 8-14 day period.
in the 40 mg/kg group (n=15), 13 patients had a total of 36 adverse events (AEs) during a single treatment period, resulting in a treatment interruption.
in the 50 mg/kg group (n-17), all patients experienced adverse reactions during a single treatment period, with a total of 93 cases and 11 patients withdrawing or stopping the study.
most of the AEs are mild to moderate, toned and safety-independent, with gastrointestinal diseases, itching, high biliary erythroidemia and jaundice.
compared to 40 mg/kg, the geometric average AUC0-24h at 50 mg/kg in Lifuping increased significantly, and the exposure peak increased exponentally at 571 mg/L.h (range 320-995) vs 387 mg/L.h (201-847).
non-protein binding exposure levels after 50 mg/kg were comparable to 30 mg/kg at lower doses.
exposure was associated with bililin concentration.
EBA increased significantly with the increase in dose, with the highest dose of 50 mg/kg: EBA on the 14th day was -0.427 logCFU/ml days.
, although the dose of Lyphin at 50 mg/kg has a stronger sterilization effect, but its tolerance is not good.
40 mg/kg, Lyphin is well-to-do and is therefore selected as the evaluated dose for the IIC phase shortening treatment trial.