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    Home > Active Ingredient News > Endocrine System > Eur Respir J: Large-scale genome-wide association analysis of the Chinese population found a new location in lung function

    Eur Respir J: Large-scale genome-wide association analysis of the Chinese population found a new location in lung function

    • Last Update: 2021-11-02
    • Source: Internet
    • Author: User
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    Lung function is a heritable complex phenotype, and obesity is one of its important risk factors
    .
    However, the relevant knowledge about the common genetic basis of the two is still limited
    .
    Most pulmonary function genome-wide association analysis studies ( GWAS s) are based on European populations, and there is a lack of large-scale pulmonary function genome-wide association analysis in other populations
    .

    Lung function is a heritable complex phenotype, and obesity is one of its important risk factors
    .
    However, the relevant knowledge about the common genetic basis of the two is still limited
    .
    Most pulmonary function genome-wide association analysis studies ( GWAS s) are based on European populations, and there is a lack of large-scale pulmonary function genome-wide association analysis in other populations
    .
    GWAS

    An article published in the journal Eur Respir J conducted a large-scale GWAS and cross-trait/population analysis using data from the Chinese Chronic Disease Prospective Study (CKB) and the UK Biobank (UKB) to 1) identify the characteristics of lung function in the Chinese population New genetic risk sites, including FEV1, FVC, and FEV1/FVC; 2) To study the characteristics of lung function and obesity (body mass index (BMI), BMI-corrected waist-to-hip ratio and BMI-corrected waist circumference (WCadjBMI)) in Chinese and European populations The common genetic effects between them; 3) Through the CKB and UKB cohort, investigate whether the longitudinal changes of baseline BMI and BMI will affect lung function, and consider the polygenicity of lung function
    .

    An article published in the journal Eur Respir J conducted a large-scale GWAS and cross-trait/population analysis using data from the Chinese Chronic Disease Prospective Study (CKB) and the UK Biobank (UKB) to 1) identify the characteristics of lung function in the Chinese population New genetic risk sites, including FEV1, FVC, and FEV1/FVC; 2) To study the characteristics of lung function and obesity (body mass index (BMI), BMI-corrected waist-to-hip ratio and BMI-corrected waist circumference (WCadjBMI)) in Chinese and European populations The common genetic effects between them; 3) Through the CKB and UKB cohort, investigate whether the longitudinal changes of baseline BMI and BMI will affect lung function, and consider the polygenicity of lung function
    .

    The study included 100285 subjects of CKB
    .
    In order to identify new gene loci of lung function, the researchers performed single-trait GWAS analysis of FEV1, FVC and FEV1/FVC in CKB patients
    .
    Subsequently, a genome-wide cross-trait analysis was performed on lung function and obesity characteristics
    .
    Finally, the lung function polygenic risk scores (PRSs) were developed in CKB, and the interaction of their correlation with BMI on lung function was studied
    .
    The researchers also used 457,756 subjects from the UK Biobank (UKB) to perform cross-character analysis in parallel with CKB to study population-specific effects
    .

    The study included 100285 subjects of CKB
    .
    In order to identify new gene loci of lung function, the researchers performed single-trait GWAS analysis of FEV1, FVC and FEV1/FVC in CKB patients
    .
    Subsequently, a genome-wide cross-trait analysis was performed on lung function and obesity characteristics
    .
    Finally, the lung function polygenic risk scores (PRSs) were developed in CKB, and the interaction of their correlation with BMI on lung function was studied
    .
    The researchers also used 457,756 subjects from the UK Biobank (UKB) to perform cross-character analysis in parallel with CKB to study population-specific effects
    .

    Researchers found 9 FEV1, 6 FVC and 3 FEV1/FVC new genome-wide sites in CKB
    .
    In CKB and UKB, FEV1 and FVC were significantly negatively correlated with obesity traits (Rg=−0.
    26, p=5.
    99×10 −9 for FEV1–WCadjBMI; Rg=−0.
    11, p=5.
    44×10 −3 for FVC– BMI; Rg=−0.
    28, p=2.
    24×10 −10 for FVC–WCadjBMI)
    .
    The gene locus shared between lung function and obesity traits highlights important biological pathways, including cell proliferation, embryonic, bone and tissue development, and gene expression regulation
    .
    Mendelian random analysis shows that in CKB and UKB, BMI has a significant negative causal effect on FEV1 and FVC
    .
    During an average follow-up of 8 years, lung function PRSs significantly changed the impact of BMI changes on lung function
    .

    Researchers found 9 FEV1, 6 FVC and 3 FEV1/FVC new genome-wide sites in CKB
    .
    In CKB and UKB, FEV1 and FVC were significantly negatively correlated with obesity traits (Rg=−0.
    26, p=5.
    99×10 −9 for FEV1–WCadjBMI; Rg=−0.
    11, p=5.
    44×10 −3 for FVC– BMI; Rg=−0.
    28, p=2.
    24×10 −10 for FVC–WCadjBMI)
    .
    The gene locus shared between lung function and obesity traits highlights important biological pathways, including cell proliferation, embryonic, bone and tissue development, and gene expression regulation
    .
    Mendelian random analysis shows that in CKB and UKB, BMI has a significant negative causal effect on FEV1 and FVC
    .
    During an average follow-up of 8 years, lung function PRSs significantly changed the impact of BMI changes on lung function
    .
    Researchers found 9 FEV1, 6 FVC and 3 FEV1/FVC new genome-wide sites in CKB
    .
    In CKB and UKB, FEV1 and FVC were significantly negatively correlated with obesity traits (Rg=−0.
    26, p=5.
    99×10 −9 for FEV1–WCadjBMI; Rg=−0.
    11, p=5.
    44×10 −3 for FVC– BMI; Rg=−0.
    28, p=2.
    24×10 −10 for FVC–WCadjBMI)
    .
    −9 −3 −10

    This large-scale pulmonary function GWAS identified a new gene locus and common genetic etiology between lung function and obesity
    .
    Depending on the subject's polygenic background, changes in BMI may have different effects on lung function
    .
    These findings may open up new avenues for the development of molecular targeted therapies to improve obesity and lung function
    .

    This large-scale pulmonary function GWAS identified a new gene locus and common genetic etiology between lung function and obesity
    .
    Depending on the subject's polygenic background, changes in BMI may have different effects on lung function
    .
    These findings may open up new avenues for the development of molecular targeted therapies to improve obesity and lung function
    .
    Molecular targeting

    Original source:

    Original source:

    Zhu Z, Li J, Si J, et al.
    A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity .
    Eur Respir J 2021; 58: 2100199 [DOI: 10.
    1183/13993003.
    00199-2021].

    Zhu Z, Li J, Si J, et al.
    A large-scale genome-wide association analysis of lung A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity .
    Eur Respir J 2021; 58: 2100199 [DOI: 10.
    1183/13993003.
    00199-2021].
    function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity



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