Eur Respir J: Large-scale genome-wide association analysis of the Chinese population found a new location in lung function

Lung function is a heritable complex phenotype, and obesity is one of its important risk factors
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However, the relevant knowledge about the common genetic basis of the two is still limited

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Lung function is a heritable complex phenotype, and obesity is one of its important risk factors

An article published in the journal Eur Respir J conducted a large-scale GWAS and cross-trait/population analysis using data from the Chinese Chronic Disease Prospective Study (CKB) and the UK Biobank (UKB) to 1) identify the characteristics of lung function in the Chinese population New genetic risk sites, including FEV1, FVC, and FEV1/FVC; 2) To study the characteristics of lung function and obesity (body mass index (BMI), BMI-corrected waist-to-hip ratio and BMI-corrected waist circumference (WCadjBMI)) in Chinese and European populations The common genetic effects between them; 3) Through the CKB and UKB cohort, investigate whether the longitudinal changes of baseline BMI and BMI will affect lung function, and consider the polygenicity of lung function

The study included 100285 subjects of CKB

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The study included 100285 subjects of CKB

Researchers found 9 FEV1, 6 FVC and 3 FEV1/FVC new genome-wide sites in CKB

This large-scale pulmonary function GWAS identified a new gene locus and common genetic etiology between lung function and obesity

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This large-scale pulmonary function GWAS identified a new gene locus and common genetic etiology between lung function and obesity

Original source:

Zhu Z, Li J, Si J, et al.

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity .

Zhu Z, Li J, Si J, et al.

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