European Radiology: 3T MR neuroimaging of the lumbosacral plexus with ATTRv-PN

Hereditary transthyretin-associated amyloidosis polyneuropathy (ATTRv-PN) is a sensory-motor axonal polyneuropathy in which amyloid fibers are heterogeneously distributed in nerve roots and nerve trunks before neuropathic manifestations.

In recent years, various techniques have been successfully developed clinically to detect early tissue deposition of TTR amyloid

A study published in the journal European Radiology examined the ability of the MRN to assess the lumbosacral plexus (LSP) to differentiate patients with ATTRv-PN from AVC and controls, and assessed its prognostic value

This study performed MRN scans including T2-w DIXON and DWI MR sequences in 25 consecutive ATTRv-PN patients, 18 AVC and 10 controls

Inter-reader agreement on MRN images was very good (Cohen's kappa = 0.

The present study found that MRN at the root of LSP was helpful in distinguishing patients with ATTRv-PN from AVC

Original source:

Jérôme Hodel, Samir Benadjaoud, Mohamed Amine Benadjaoud, et al.