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European Radiology: Application of multiparametric bone MRI in the selection of biopsy targets for bone metastases

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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The increasing role and frequency of CT-guided metastatic bone biopsies provide support for determining prognosis, predicting response, and detecting treatment resistance in cancer patient.

DWI is a functional imaging technique by applying a diffusion-sensitive gradient (described by b-values) to fat-saturated T2-weighted, malignant tumors produce hyperintensity (high b-values) on diffusion-weighted images, while that of surrounding normal tissue suppress.

A study published in the European Radiology journal evaluated the possibility of identifying active bone metastases using a combination of DWI signal, ADC, and rFF with multiparametric bone MRI (mpBMRI), providing high diagnostic biopsy rates and NGS feasibility for the clin.

This study reviewed the results of a total of 150 CT-guided bone biopsies performed by interventional radiologists at our center (March 2013 to February 2021.

mpBMRI combined with high DWI signal, mean ADC<1100µm ² 2 /s, and mean rFF<20% identified tumor-positive biopsies with 82% sensitivity, 80% specificity, and 93% positive predictive value (PPV) (p= 001), NGS feasibility was 91% sensitivity, 78% specificity and 91% PPV (p<00

Multiparametric MRI image of a 60 -year-old man with prostate cancer and metastases to the right acetabulu.

This study demonstrates that mpBMRI using a combination of DWI signal, ADC, and rFF can identify active bone metastases suitable for biopsy, while providing high diagnostic yield and NGS feasibility for use as part of interventional imaging efforts in patients with bone metastases Biopsy lesion selection in cancer patien.

Original source:

Ricardo Donners, Ines Figueiredo, Nina Tunariu, et .

Ricardo Donners, Ines Figueiredo, Nina Tunariu, et .
Multiparametric bone MRI can improve CT-guided bone biopsy target selection in cancer patients and increase diagnostic yield and feasibility of next-generation tumor sequencin.
DOI : Multiparametric bone MRI can improve CT-guided bone biopsy target selection in cancer patients and increase diagnostic yield and feasibility of next-generation tumour sequencing 11007/s00330-022-08536-6 11007/s00330-022-08536-6 11007/s00330-022-08536-6 Leave a message here

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