European Radiology: Effects of gadolinium-based contrast agents on automated measures of brain atrophy in patients with multiple sclerosis

Studies have shown that gray matter (GM) atrophy measured on MRI in patients with multiple sclerosis (MS) reflects irreversible axonal loss and neurodegenerative changes in the central nervous system

Studies have shown that gray matter (GM) atrophy measured on MRI in patients with multiple sclerosis (MS) reflects irreversible axonal loss and neurodegenerative changes in the central nervous system

There are many methods and software currently available to measure GM atrophy

Because of the high tissue contrast of non- enhanced three-dimensional (3D) T1-weighted images, brain segmentation software often uses this sequence of images for evaluation .

The use of GBCA has increased over the past three decades

A study published in the journal European Radiology validates volume and cortical thickness measurements using GBCA -enhanced T1-weighted images and provides guidance on how to interpret clinically relevant and commonly considered measurements .

There was good to excellent reliability between all survey measures, with ICC ranging from 0.

This study demonstrates that FreeSurfer can obtain reliable GM atrophy measurements from enhanced three-dimensional T1-weighted images .

Original source :

Ingrid Anne Lie , Emma Kerklingh , Kristin Wesnes ,et al .

Ingrid Anne Lie Emma Kerklingh Kristin Wesnes ,et al The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis 10.
1007/s00330-021-08405-8 10.
1007/

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