European Radiology: Pathology-Grade Analysis of MYCN Amplification in Neuroblastoma Using Apparent Diffusion Coefficient (ADC) Histogram Analysis!

According to statistics, neuroblastoma is the most common extracranial solid tumor in children

Clinically, an open or percutaneous needle biopsy is usually required to determine the cytogenetics of neuroblastoma

Diffusion-weighted imaging quantifies the random motion of protons in the body

Recently, a study published in the journal European Radiology evaluated the role of whole-tumor apparent diffusion coefficient (ADC) histogram analysis in identifying MYCN amplification status in neuroblastoma for a noninvasive, accurate, and comprehensive preoperative assessment of neuroblastoma.

This study retrospectively evaluated the imaging records of 62 patients with neuroblastoma (median age: 15 months (interquartile range (IQR): 7-24 months); 38 women) who were Magnetic resonance imaging was performed at this institution prior to initiation of any treatment or biopsy

MYCN-amplified neuroblastomas had statistically significantly higher maximal ADCs and lower minimal ADCs compared to non-amplified neuroblastomas, and also exhibited higher maximal ADCs than non-amplified tumors.

The present study provides preliminary retrospective data on the role of ADC histogram parameters in predicting MYCN-amplification

Original source:

Adarsh ​​Ghosh, Ensar Yekeler, Deepa Dalal, et al.