European Radiology: Reproducible imaging prediction of glioma molecular subtypes and risk stratification through a structured reporting system

The World Health Organization (WHO) classification of glioma integrates histopathological and molecular markers of low-grade glioma and glioblastoma
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Among the molecular changes, isocitrate dehydrogenase (IDH) mutations and chromosome 1p and 19q arm deletions (1p/19q co-deletion) are very common

The World Health Organization (WHO) classification of glioma integrates histopathological and molecular markers of low-grade glioma and glioblastoma

The use of structured reporting can improve the consistency of interpretation between the people and convenient results between radiologists and clinicians to communicate , to further improve glioma patients standardized clinical management

Recently, a study published in the journal E uropean Radiology evaluated whether these MRI parameters, which are determined to have good reproducibility, can be used to predict the molecular subtype and risk stratification of glioma among readers with different levels of experience.
the prediction flag , is kind of structured reporting tumors reuse and molecular forecasting and risk stratification provided strong support .

All patients included in the study were initially diagnosed as gliomas, of which 141 were from the Cancer Genome Atlas and 131 were from our tertiary institutions as training and validation sets, respectively

Reproducible imaging parameters that show greater than 50% agreement between different readers include the presence of necrosis, T2/FLAIR mismatch, internal cysts, and major contrast enhancement

 

Figurea A 65-year-old male patient with type 1 glioma presenting as an internal cyst
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b A 70-year-old female patient with type 2 glioma, presenting with T2/FLAIR mismatch

Figurea A 65-year-old male patient with type 1 glioma presenting as an internal cyst

This study confirmed the reproducibility and clinically available imaging parameters of IDH wild-type glioblastoma, IDH- mutant /1p19q co-deleted oligodendroglioma, and IDH-mutant low-grade astrocytoma, and The specific requirements

Original source :

Yeo Kyung Nam , Ji Eun Park , Seo Young Park ,et al.

Yeo Kyung Nam Ji Eun Park Seo Young Park 10.
1007/s00330-021-08015-4 10.
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