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Patients infected with SARS-Cov-2 who develop COVID-19 are at risk of developing thromboembolic complications due to hyperactivation of coagulation
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Severe COVID-19 cases were associated with increased levels of inflammatory and prothrombotic biomarkers, such as interleukin-6 and D-dimer
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Patients infected with SARS-Cov-2 who develop COVID-19 are at risk of developing thromboembolic complications due to hyperactivation of coagulation
However, there are currently no guidelines recommending routine CTPA testing in the evaluation of patients with COVID-19
A study published in the journal European Radiology assessed the optimal D-dimer level to safely rule out acute PE independent of pre-test clinical probability in COVID-19 patients presenting to the emergency department, avoiding delays for early diagnosis of PE.
This retrospective study included patients with COVID-19 who were seen in the ED of AP-HP Hospital between March 1 and May 15, 2020, and who had D-dimer dosimetry and CTPA within 48 h of the visit.
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A total of 781 SARS-Cov-2 RT-PCR-positive patients (mean age, 62.
0 years, 53.
Figure D - ROC curve analysis of the diagnostic performance of the dimer
Figure D - ROC curve analysis of the diagnostic performance of the dimerIn conclusion, this study supports the use of the same D-dimer threshold as validated in the general population to safely exclude PE risk in COVID-19 patients presenting to the ED
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In conclusion, this study supports the use of the same D-dimer threshold as validated in the general population to safely exclude PE risk in COVID-19 patients presenting to the ED
Original source:
Marie-Pierre Revel, Nathanael Beeker, Raphael Porcher, et al.
What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department? DOI : 10.
Marie-Pierre Revel, Nathanael Beeker, Raphael Porcher, et al.
What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department? DOI : 10.
1007/s00330-021-08377-9 What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department? DOI 10.
1007/s00330-021-08377-9 Leave a comment here
