Evaluation of drug molecular target database

According to the world cancer report in 2012, there are about 14 million new cases of cancer and 8 million deaths every year The new cases in China account for 22% of the new cases in the world, and the death toll accounts for 26%, more than one quarter of the global cancer deaths, becoming the first cancer country For cancer patients, it's a battle of life and death, and the most important thing in life is to restore their health Of course, behind the patient's arduous anti-cancer efforts, they can't do without the full support of a group of medical researchers and researchers, who are fighting against cancer cells day and night, striving for time for life After years of research and development, researchers have found that traditional anticancer drugs are distributed in the whole body after intravenous, oral or local injection, and the amount of drugs that really reach the treatment target area is only a small part of the dosage, while most of the drugs in the non target area not only have no treatment effect, but also bring side effects The targeted drugs can be described as a good way to specialize in cancer cells, which has become the main research direction of researchers, and also brings new hope for cancer patients Targeted drugs are favored by the market because of their multiple advantages, such as accurate positioning, good efficacy and few side effects Therefore, researchers and drug users are also in urgent need of professional drug molecular target data With a long call, the drug molecular target database of drug intelligence network came into being, bringing first-hand advanced data and information for researchers to benefit thousands of people The so-called drug target is the binding site of drug and organism macromolecule The range of drug targets is quite wide, involving receptors, enzymes, ion channels, transporters, immune system, genes, etc In addition, some drugs work by their physical and chemical effects or by replenishing substances that the body lacks In the existing drugs, more than 50% of the drugs take the receptor as the target, and the receptor becomes the most important and important target; more than 20% of the drugs take the enzyme as the target, especially the enzyme inhibitor, which plays a special role in the clinical application; about 6% of the drugs take the ion channel as the target; 3% of the drugs take the nucleic acid as the target; 20% of the drugs need to be further targeted Research The database of drug molecular target is rich in information beyond imagination In order to present the most complete information to the R & D personnel, the data specialist of pharmaceutical intelligence has made great efforts in the collection of pharmacology, including pharmacodynamics, toxicology, drug absorption, drug metabolism, etc., and made the molecular target, indication, pharmacology, toxicology, interaction, structural formula, etc of each data clear one by one, filling in the pharmacology information of various domestic medical databases The status quo of scarcity Not only that, it also adds information about the interaction between drugs and other drugs, drugs and food, which is of great benefit to the R & D personnel in mining more information, but also can guide the drug users in the accuracy of drug use, so as to maximize the drug use Pharmaceutical intelligence data takes you to open a mysterious and infinite data journey Pharmaceutical intelligence database is a massive library of pharmaceutical data information On the double guarantee of information quality and quantity, the new intelligent retrieval tool of pharmaceutical intelligence data also provides the greatest convenience for users to open a rich and diverse, mysterious and infinite data world Enter the database of drug molecular targets, and a clear retrieval platform (see the figure below) will appear Users can query through drug name, indications, molecular targets, etc., or through pharmacological classification Pharmacological classification is based on ATC classification system, so you can select according to the first level of anatomical classification If you are not satisfied with the results, you can search the second level of therapeutic classification If you haven't met your requirements, you can also choose the third level of pharmacological classification It supports both fuzzy and precise retrieval Just click search, the concise list page information and detailed content page information will be displayed in front of you Take clofedanol as an example Enter the keyword clofedanol in the drug name for retrieval, and the basic information such as drug molecular target, ATC code will appear in an instant Click to view the information about clofedanol, including drug description, structural pattern picture, molecular target, ATC code, indication, pharmacology, mechanism of action, and all the information about the drug can be seen at a glance In addition, users can also see other extended data through extended information, realizing efficient, fast and accurate data search Website: http://db.yaozh.com/targets