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A vaccination study carried out on 80 people, Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis showed that Modena's mRNA-1273 vaccine and an improved vaccine against the variant strain are effective The enhanced needle is safe and well tolerated, and can increase the level of neutralizing antibodies against the new coronavirus (SARS-CoV-2) key variants (including Beta, Gamma, and Delta variants)
.
This result was published in Nature Medicine as an interim analysis of an ongoing clinical trial
.
With the emergence of SARS-CoV-2 "variants of concern" (VOC) and "variants of interest" (VOI) and the weakening of the neutralizing effect of antibodies, people began to pay more attention and strengthen Needles and vaccines against variant strains
.
In order to evaluate the safety and efficacy of the SARS-CoV-2 booster shot, the researchers asked subjects who had received two shots of the Moderna vaccine (mRNA-1273) to receive a booster shot 6 months later
.
Their booster shots are either the original vaccine or an improved vaccine against variant strains, such as the mRNA-1273.
211 vaccine against multiple variant strains
.
Darin Edwards of Modena Co.
, Ltd.
of the United States and colleagues observed four booster injection groups (20 subjects in each group, with different combinations of original and modified vaccines)
.
Immediately before the booster shot, the level of SARS-CoV-2 neutralizing antibody in the blood of the subjects was lower than their level one month after the second shot, and for those who need to pay attention to the mutant strains Beta, Gamma, and Delta Neutralizing antibody levels are either very low or undetectable
.
The authors found that the three booster injections they tested can make the subjects' SARS-CoV-2 neutralizing antibody titers higher than the level one month after the first round of vaccines, caused by mRNA-1273 and mRNA-1273.
211 The increase is particularly significant
.
In addition, all three booster injections can increase the neutralizing antibody titers against Beta, Gamma, Delta variants and other variants that require attention
.
The authors acknowledge that the preliminary analysis still has some limitations, including the small sample size and the fact that the treatment groups on which the results are based are not randomly assigned
.
However, they believe that the trial's mRNA technology platform for SARS-CoV-2 that needs to focus on the testing of variant strains seems to be effective in strengthening needle research and development
.
The neutralization effect of wild-type D614G and B.
1.
351 on wild-type D614G and B.
1.
351 was measured by the Lentivirus-based PsVN assay
.
Source: Edwards et al.
©NatureNat Med | doi: 10.
1038/s41591-021-01527-y
.
This result was published in Nature Medicine as an interim analysis of an ongoing clinical trial
.
With the emergence of SARS-CoV-2 "variants of concern" (VOC) and "variants of interest" (VOI) and the weakening of the neutralizing effect of antibodies, people began to pay more attention and strengthen Needles and vaccines against variant strains
.
In order to evaluate the safety and efficacy of the SARS-CoV-2 booster shot, the researchers asked subjects who had received two shots of the Moderna vaccine (mRNA-1273) to receive a booster shot 6 months later
.
Their booster shots are either the original vaccine or an improved vaccine against variant strains, such as the mRNA-1273.
211 vaccine against multiple variant strains
.
Darin Edwards of Modena Co.
, Ltd.
of the United States and colleagues observed four booster injection groups (20 subjects in each group, with different combinations of original and modified vaccines)
.
Immediately before the booster shot, the level of SARS-CoV-2 neutralizing antibody in the blood of the subjects was lower than their level one month after the second shot, and for those who need to pay attention to the mutant strains Beta, Gamma, and Delta Neutralizing antibody levels are either very low or undetectable
.
The authors found that the three booster injections they tested can make the subjects' SARS-CoV-2 neutralizing antibody titers higher than the level one month after the first round of vaccines, caused by mRNA-1273 and mRNA-1273.
211 The increase is particularly significant
.
In addition, all three booster injections can increase the neutralizing antibody titers against Beta, Gamma, Delta variants and other variants that require attention
.
The authors acknowledge that the preliminary analysis still has some limitations, including the small sample size and the fact that the treatment groups on which the results are based are not randomly assigned
.
However, they believe that the trial's mRNA technology platform for SARS-CoV-2 that needs to focus on the testing of variant strains seems to be effective in strengthening needle research and development
.
The neutralization effect of wild-type D614G and B.
1.
351 on wild-type D614G and B.
1.
351 was measured by the Lentivirus-based PsVN assay
.
Source: Edwards et al.
©NatureNat Med | doi: 10.
1038/s41591-021-01527-y
