Excessive drinking is prone to esophageal squamous cancer! Fudan University, in association with Shandong University, published the latest research results.

Original title: Excessive drinking is prone to esophageal squamous cancer! Fudan University, in association with Shandong University, published the latest research results
esophageal cancer is a common digestive system malignant tumor in the world, is also one of the most high incidence of malignant tumors in China. Recently, Fudan University Human Esotica Research Institute youth researcher Chen Xingdong team, genetic engineering national key
auscular
-room public
health
college youth associate researcher So Chen team, in cooperation with Shandong University Professor Lu Ming team, revealed that alcohol consumption and
alolum
metabolism
related genetic factors can significantly increase the risk of esophageal squamous cancer, emphasizing the harmful effects of excessive drinking. This risk is
people who lack
acetaldehyde and dehydrogenase in the body. In April, the study was published in Journal of Theoracic Oncology.
esophageal cancer incidence, mortality rate is high, serious harm, in many areas is still the most serious threat to the health of the population of malignant tumors, resulting in a very heavy burden of disease. The incidence of esophageal cancer has obvious geographical and human differences, the western population is dominated by adenocarcinoma, while the Asian population, especially the Chinese group, is dominated by squamous epithelial cancer, accounting for more than 90%.
Esophageal Squamous Cell Carcinoma (ESCC) has a number of causes, and it is now recognized that alcohol consumption, smoking damage to the esophageal system of various chronic stimuli, environmental factors and certain genetic factors are the main causes of esophageal squamous cancer in China. Therefore, a comprehensive and specific understanding of the risk factors for esophageal cancer is very important for its prevention and treatment. Previous studies have reported that alcohol consumption and genetic variation are major factors in esophageal squamous cancer. However, the complex interaction between the genetic factors associated with alcohol and alcohol metabolic pathogenesis is not yet clear in terms of increasing the risk of ESCC.
study conducted a population-based case control study in Taizhou, Jiangsu Province, with a high incidence of ESCC, which included 1,190 cases and 1,883 controls. The study combines data on single nucleotide polymorphisms, detailed drinking history, and biological function information on genes associated with alcohol metabolism to illustrate the complex relationship between alcohol consumption, alcohol metabolase gene variation, and ESCC risk.
ADH1B different genotypes (rs1042026) can affect the activity of ADH1B, thereby affecting the concentration of acetaldehyde in the body. According to the genotype distribution of this bit, the study suggests that most Chinese people metabolize alcohol from ethanol to acetaldehyde rate too fast, which can lead to ethanol accumulation, of which, 1/4 of the people also carry the ALDH2 gene rs671AG genotype, resulting in lower activity of acetaldehyde dehydrogenase, the concentration of acetaldehyde in the body increased. Healthy individuals with different ALDH2 and ADH1B genotypes also exhibited diverse drinking behaviors: the proportion of drinkers in individuals with different genotype combinations varied from 23.7 percent to 54.3 percent.
the study confirmed that two ESCC susceptible points, rs671 on the Acetaldehyde Dehydrogenase Family Member Gene (ALDH2) and Rs1042026 in the Ethanol Dehydrogenase 1B gene (ADH1B), were highly correlated with drinking behavior and modified the association between alcohol consumption and ESCC high risk. The study further assessed the interaction between the ADH1B and ALDH2 variants and the increased risk of ESCC from alcohol consumption. The results showed that in individuals with rapid oxidation of ethanol, there was a strong interaction and multiplication between alcohol consumption and acetaldehyde oxidation rate.
study suggests that authorities need to do more to prevent excessive drinking, especially in individuals with the ADH1B gene rs1042026AG/GG genotype and the ALDH2 gene rs1671AG genotype. This study, which is the first to incorporate information on the function of genes associated with alcohol metabolism into the analysis, is one of the large-scale studies to explore the effects of the interaction between genes and alcohol consumption on the risk of Chinese groups of esophageal squamous cancer, and is the result of multi-team and multidisciplinary efforts.