Experimental Traumatic Spinal Cord Injury
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Last Update: 2020-12-20
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Source: Internet
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Author: User
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Animal models are important to develope therapies for individuals suffering from spinal cord injuries. For this purpose, ratsare commonly preferred. In sharp injury models, spinal cord is completely or incompletely cut to assess axonal regeneration. On the other hand, spinal cord is compressed or contused to mimic the human injury in blunt injury models for understandingas well as managing the secondary pathophysiologic processes following injury. Especially, contusions are thought to be biomechanicallysimilar to vertebral fractures and/or dislocations and thus provide the most realistic experimental setting in which to testpotential neuroprotective and regenerative strategies.
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