Expert Review of Vaccines: Viral vaccines are safe for children with immunodeficiency

February 3, 2020 //--- According to a study review, inactivated and detoxifying live vaccines generally produce adequate immune responses and can be safely used in children with autoimmune diseases treated for all but the most effective immunosuppressants.
team at the University of Manchester and the University of Manchester NHS Foundation Trust reviewed 37 original articles: 25 studies of inactivated vaccine influenza; and human papillomavirus.
12 studies have studied live vaccines against chickenpox shingles virus; measles, mumps and rubella.
(Photo: www.pixabay.com) the study was published in the journal Expert Reviews of Vaccines.
study concluded that low doses of steroids and biologics had no significant adverse effects on the vaccine's immune response.
lecturer at the University of Manchester and co-author of the consultant in paediatric immunology at the Royal Manchester Children's Hospital. Dr Arkwright said the review should give patients and clinicians the confidence to ensure that the children do receive the scheduled vaccinations.
team, including Professor Ray Borrow, Professor of Vaccine Preventable Diseases at the University of Manchester, did find evidence that live vaccines were less effective in patients treated with high doses of steroids and chemotherapy cyclophosphamide.
Arkwright said: "Children with autoimmune diseases such as Crohn's disease, lupus and juvenile arthritis often need to be treated with immunosuppressants.
that while preventing infection is critical for these patients, clinicians have long been concerned about the effectiveness and safety of the drug.
, especially live vaccines, there is evidence that both live and non-live vaccines are safe and effective, and it is hoped that this study will address these issues.
receiving immunosuppressive medications for autoimmune diseases should be vaccinated to protect them from vaccine-preventable diseases.
, however, do believe that patients taking large doses of steroids and pulsed cyclophosphamide should avoid the use of live virus vaccines.
the vaccine provides adequate protection, antibody concentrations may be lower in patients taking immunosuppressants," he said.
, the team believes that patients using these drugs may need to add enhanced vaccines in the future to ensure that protection is maintained.
(Bioon.com) Source: Vaccines safe for majority of the university of immunosuppressed children, find scientists Original source: Hiu Nam Tse et al. Immune Response and Safety of Viral Vaccines in Children with Autoimmune Diseases on Immune Modulatory Drug Therapy, Expert Review of Vaccines (2021). DOI: 10.1080/14760584.2021.1875825