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Endocrine-disrupting chemicals (EDC) are a class of exogenous chemicals that disrupt the endocrine system, including perfluoroalkyl substances (PFAS), phthalates, and phenols such as bisphenol
In recent years, many studies have pointed out that EDC may endanger human health by affecting the endocrine system
However, there has been a problem with EDC research for a long time: previous research has focused on the effects of a certain EDC on the human body
Now, a new study published in Science proposes a new research framework for assessing the combined health effects of EDC blends
The EU-funded project, called 'EDC-MixRisk' (EDC-MixRisk), involved scientists from several European research institutes
First, the research team tested 1874) pregnant women's blood and urine for a mixture of EDCs (including various phthalates, bisphenol A, and perfluorinated compounds described at the beginning) and compared the results with their offspring at the age of two and a half.
Subsequently, from the laboratory organoid and animal model studies), the research team revealed which molecular targets of the EDC mixture interfered with the regulation of the endocrine circuit, and how it led to the dysregulation of the expression of genes related to autism and intellectual disability.
In the end, these laboratory-derived findings were used by the research team to develop new methods for assessing the risk of mixtures
▲The picture shows the comprehensive framework in this study (picture source: Reference [1])
In early pregnancy, the right concentration of thyroid hormone is essential for the growth and development of the brain, therefore, the EDC mixture is likely to cause the delay of neonatal language development through its effect on thyroid hormone
▲Schematic diagram of the experimental process (picture source: Reference [1])
It can be said that this study shows us the importance of considering multiple compounds comprehensively, and also provides a feasible comprehensive framework for risk assessment
References:
[1] Nicolò Caporale et al.
[2] Animangsu Ghatak, How does a lizard shed its tail? Science (2022) DOI: 10.
[3] More chemicals, fewer words: exposure to chemical mixtures during pregnancy alters brain development.