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    Home > Active Ingredient News > Antitumor Therapy > Extracellular miR-31-5p derived from hypoxic tumor promotes lung adenocarcinoma metastasis through EMT and activation of MEKERK signaling pathway

    Extracellular miR-31-5p derived from hypoxic tumor promotes lung adenocarcinoma metastasis through EMT and activation of MEKERK signaling pathway

    • Last Update: 2021-06-16
    • Source: Internet
    • Author: User
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    Extracellular bodies have become an important medium for communication between cells


    Extracellular bodies have become an important medium for communication between cells



    Lung cancer is a highly malignant tumor, and the death rate associated with cancer ranks first in the world


    Diagnosis of biomarker tumors

    The extracellular body is composed of a type of membrane-bound extracellular vesicles with a size of 50-150 nm


    Tumor non-coding RNA miRNA tumor

    Hypoxia has been shown to stimulate the release of exosomes and cause significant changes in cell content and function, indicating that exosomes play an important regulatory role in long-distance intercellular communication


    leukemia



    Image source: https://doi.


    In this study, the authors found that hypoxia increased the release of LUAD exosomes


    Tumor diagnosis

    In conclusion, the authors provided evidence that miR-31-5p is abundantly enriched in glucose bodies derived from hypoxic LUAD cells


    The authors provided evidence that miR-31-5p is abundantly enriched in glucose bodies derived from hypoxic LUAD cells


    Fengqiang Yu et al.


    Fengqiang Yu et al.



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