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Extracellular bodies have become an important medium for communication between cells
Lung cancer is a highly malignant tumor, and the death rate associated with cancer ranks first in the world
The extracellular body is composed of a type of membrane-bound extracellular vesicles with a size of 50-150 nm
Hypoxia has been shown to stimulate the release of exosomes and cause significant changes in cell content and function, indicating that exosomes play an important regulatory role in long-distance intercellular communication
Schematic diagram of hypoxic exosomes containing miR-31-5p through negative regulation of SATB2 reversed EMT and activation of MEK/ERK signal transduction to normoxic cells to promote LUAD invasion and migration
Image source: https://doi.
In this study, the authors found that hypoxia increased the release of LUAD exosomes
In conclusion, the authors provided evidence that miR-31-5p is abundantly enriched in glucose bodies derived from hypoxic LUAD cells
Reference
Fengqiang Yu et al.