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    Home > Biochemistry News > Biotechnology News > Extracellular miR-31-5p promotes lung adenocarcinoma metastasis through EMT and activation of MEKERK signaling pathway

    Extracellular miR-31-5p promotes lung adenocarcinoma metastasis through EMT and activation of MEKERK signaling pathway

    • Last Update: 2021-06-21
    • Source: Internet
    • Author: User
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    Extracellular bodies have become an important medium for communication between cells


    Lung cancer is a highly malignant tumor, and the death rate associated with cancer ranks first in the world


    The extracellular body is composed of a type of membrane-bound extracellular vesicles with a size of 50-150 nm


    Hypoxia has been shown to stimulate the release of exosomes and cause significant changes in cell content and function, indicating that exosomes play an important regulatory role in long-distance intercellular communication


    Schematic diagram of hypoxic exosomes containing miR-31-5p through negative regulation of SATB2 reversed EMT and activation of MEK/ERK signal transduction to normoxic cells to promote LUAD invasion and migration

    Image source: https://doi.


    In this study, the authors found that hypoxia increased the release of LUAD exosomes


    In conclusion, the authors provided evidence that miR-31-5p is abundantly enriched in glucose bodies derived from hypoxic LUAD cells


    Reference

    Fengqiang Yu et al.


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