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Information is repeatedly retrieved and re-encoded in different environments, and memories often become blurred and generalization processes follow.
1
The basal posterior amygdala neurons respond to reward generalization
The GO/NO-GO experiment is to study the behavioral responseof rodents to uncertain cues.
Figure 1: pBLA-Calb1 neuronal activity is associated with generalized rewards
2
The IL–pBLA loop regulates generalized reward information
Retrograde tracer virus revealed that pBLA retrograde projection into the IL region, fiber optic calcium imaging technology recorded a significant increasein the calcium ion activity of neurons in the IL–pBLA loop of rewarding preference mice.
Figure 2: The IL–pBLA loop regulates reward generalization behavior
3
The IL–pBLA loop regulates depression and anxiety-like behavior
Generalization of excessive negative emotional memory is a typical featureof anxiety and depression.
Figure 3: The IL–pBLA loop regulates depressive and anxious behavior
summary
This paper reveals a neural circuit IL–pBLA-Calb1 that responds to generalized reward signals, which is less active in chronic stress-induced depression-like and anxiety-like mice, and improves depression and anxiety-like behavioral disorders
after activating this neural circuit.
【References】
1.
The images in the article are from references
