FASEB J: Research reveals the mechanism of heart failure in obesity in old age.

, June 24, 2020 /PRNewswire/ ---
in a recent study published in the journal FASEB Journal, a preclinical studyled by researchers at South Florida Health University (USF Health) suggests that receptor proteins that play an important role in alleviating heart inflammation may be used to treat age-related obesity and heart failureresearchers have identified a mouse model that can mimic human HFpEF syndromeThese obese mice lack inflammatory removal receptors, or ALX/FPR2 or ALX, and can cause inflammation of the heart and kidneys of aging mice(photo:using this unique model, and researchers defined how ALX receptors promote the activity of fatty acid-derived signaling molecules (SPMs)These SPM molecules promote the body's inherent immune response, help remove chronic inflammation and promote heart repair after acute heart attackInstead, the researchers noted that persistent, unresolved inflammation after a heart attack exacerbates abnormalities in the lining of the heart and kidneysThese abnormalities indicate endothelial dysfunction and alter vascular integrity, which are the main signs of age-related obesity and HFpEF"It is important to note that a lack of a single receptor can cause obesity in early mice, which in turn causes many molecular and cellular processes, which ultimately lead to heart failure," said senior author Dr Ganesh Halade,"
study found that obese ALX-defective mice had increased food intake and impaired energy metabolism compared to normal mice of the same age (with effective ALX receptors)Metabolic dysfunction caused by obesity leads to remodeling of the heart structure, poor electrical activity of the heart and weakening of the heart muscleThe deletion of alX receptors increased the expression of the ion channel gene and destroyed multiple ion channels, which supported the eiregram evidence of heart rhythm disorders in micein addition, mice prone to obesity, ALX deficiency, developed HFpEF cardiomyopathy and stable inflammation in the heart and kidneysThis inflammation is controlled remotely by immune cells in the spleen, and in obese mice lacking alX in old age, the dysfunctional heart, kidney and kidney nealal tissue can worsen the disease this study provides insight into potential targeted treatments for HFpEF Dr Halade said that diets and/or SPM supplements rich in Omega 3 can maintain the normal function of the receptors and may help prevent this type of heart failure, while SPMs or other molecules specifically designed to reactivate dysfunction receptors can help treat existing diseases (Bio Valley Bioon.com) information source: Mouse model identified to study common form of heart no snr to the age-and-thin
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