Fat crystals cause chronic inflammation.

AUGUST 26, 2020 /--- According to a recent study published in the journal Autophagy, researchers from the University of Bonn have found that congenital disorders in fat metabolism cause chronic inflammation of the immune system.
In recent years, we have known that some potential mutations alter the activity of an important enzyme in fat metabolism, causing human cells to produce large amounts of deoxygenated carbohydrate, about ten times more than normal cells.
at high concentrations, they also form crystalline lumps in the affected cells.
fat crystals greatly disrupt the function of mitochondrials, and cell types with high energy needs may suffer more damage.
, this symptom mainly affects nerve cells, so that's why we feel pain and other neurological symptoms.
their current work, the researchers also detected mitochondrial defects in connective tissue cells in mice.
researchers examined macrophages in mice.
results show that macrophages, similar to nerve or connective tissue cells, produce large amounts of deoxygenated carbohydrate during disease.
, they also absorb abnormal fat from dead cells.
other words, they get several times as much fat crystals as other cell types.
(Photo: www.pixabay.com) this process greatly disrupts the function of various cellular components in these macrophages, such as mitochondrials.
addition, the process activates the autophagy response of macrophages, as well as a molecular complex called inflammatory small bodies that promote inflammation.
the active inflammatory body and then causes macrophages to release inflammatory messenger molecules.
in this way, other immune cells will further enhance this effect.
the results may provide new revelations for common diseases.
in diabetic patients, there has also been a significant increase in the production of deoxygenated lipids in certain cells, but the cause is still unknown.
in diabetes, doctors often observe severe chronic inflammation and exacerbate the serious consequences of the disease.
this study provides a new molecular mechanism explanation for this clinical symptom.
(bioon.com) Source: Fat crystals trigger chronicning Original source: Mario A. R. Lauterbach et al. 1-Deoxysphingolipids cause autophagosome and lysosome reed and trigger NLRP3 inflammasome activation. Autophagy, DOI: 10.1080/15548627.2020.1804677.