FCDB: Explore the causal relationship between hypothyroidism and non-alcoholic fatty liver

The etiology of non-alcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors
.

A large number of observational studies have shown that hypothyroidism is a high-risk factor for NAFLD

The etiology of non-alcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors

Results: The effect of hypothyroidism on the risk of non-alcoholic fatty liver disease showed that IVW analysis found a significant OR (1.
7578; 95% CI 1.
1897-2.
5970; P = 0.
0046), confirming that hypothyroidism is associated with a high risk of NAFLD
.

Since there is no heterogeneity among genetic variants (P = 0.

Table 1 The genetic variation relationship between hypothyroidism and NAFLD
.

Table 1 The genetic variation relationship between hypothyroidism and NAFLD
.

Table 2 Five other MR methods for causality analysis
.

Table 2 Five other MR methods for causality analysis
.

Figure 1 Analysis of cross-validation
.

The red line is the average of all β values ​​after removing 1

Figure 1 Analysis of cross-validation

Figure 2 MR test: The estimate of the intercept can be interpreted as an estimate of the average pleiotropy of all SNPs, and the slope coefficient provides an estimate of the causal effect bias
.

MR, Mendelian randomization; SNP, single nucleotide polymorphism

Figure 2 MR test: The estimate of the intercept can be interpreted as an estimate of the average pleiotropy of all SNPs, and the slope coefficient provides an estimate of the causal effect bias

We proved for the first time that the risk of NAFLD is significantly increased in patients with hypothyroidism, thus clarifying the pathogenic factors and causes of NAFLD

Qiu S, Cao P, Guo Y, Lu H, Hu Y, Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study .

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