echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Medical News > Medical Research Articles > FDA approves Alexion's long-acting C5 tonic inhibitor Ultromiris (ravulizumab-cwvz) extended indications

    FDA approves Alexion's long-acting C5 tonic inhibitor Ultromiris (ravulizumab-cwvz) extended indications

    • Last Update: 2020-06-07
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    recently, Alexion Pharmaceuticals(http:// announcedthat the U.SFDA(http://approved the company's long-acting C5 tonic inhibitor Ultromiris (ravulizumab-cwvz) extended indications for the treatment of atypical hemolytic uremic syndrome (aHUS) patients (aHUS) patients (more than one month old) to complement the tonic-mediated thrombosis (TAM)About Ultomiris
    Ultomiris is a long-acting C5 tonic inhibitor developed by Alexion that inhibits the activation of the complement signal ingress signal path by inhibiting the effect protein C5 of the complement-level connectivity pathPatients need only receive an injection every 8 weeks to effectively inhibit the activation of the complement signaling pathwayUltomiris has received FDA approval to treat haemoglobinuria (PNH)The approval is based on the results of two global, single-arm open label studies, including an adult clinicaltrial(http://and a clinical trial in pediatric patientsThe results showed that 54% of adult sand patients and 71% of children in adult patients developed complete remission of thrombosis microvascular disease (TAM) after the initial 26-week course of treatmentFurthermore, Ultomiris reduced thrombocytopenia in 84% of adults and 93% of children, hemolytic in 77% of adults and 86% of children, and improved kidney function in 59% of adults and 79% of children (data for children are medium-term)
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.