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Introduction: At this stage, the novel coronavirus pneumonia (COVID-19) continues to spread around the world, posing a serious threat to human health and social and economic development
.
According to Worldometer real-time statistics, as of February 14, 2022, the number of newly confirmed cases in a single day in the world reached 1,531,001, and 6,383 new deaths were reported
.
Effective response to the epidemic requires not only preventive and therapeutic measures to improve the survival rate of patients, but also early intervention strategies to deal with the sequelae of patients
.
Recently, the team of Professor Huang Chaolan from the Precision Medicine Multi-Omics Research Center of Peking University School of Medicine, the team of Academician Gao Fu of the Chinese Academy of Sciences, and the team of researcher Liu Jun of the Institute of Virology of the Chinese Center for Disease Control and Prevention carried out cooperative research, based on the "asymptomatic, mild to moderate disease, Four cohorts of patients with COVID-19 who are "severe, recovered", through the integrated analysis of proteomic data and clinical data, found that the immune function of patients with COVID-19 has a "multi-stage" process of activation in the asymptomatic stage, suppression in the early stage, and abnormal activation in the later stage.
Altered neutrophil function may be a turning point in immune dysfunction
.
At the same time, immune dysfunction, cholesterol metabolism disorders, and impaired myocardial function have run through the occurrence and development of COVID-19
.
This finding has implications for the development of early intervention strategies to improve patient outcomes
.
The study, titled "Immune response pattern across the asymptomatic, symbolic and convalescent periods of COVID-19", was published in the journal BBA-Proteins and Proteomics and was selected to be featured as the journal's 2022 cover article
.
Fig.
Screenshot of the front page of BBA-Proteins and Proteomics The researchers performed quantitative proteomic analysis based on the DIA-PASEF method on serum and urine samples from patients with new coronary pneumonia at different stages of disease progression
.
The results showed that compared with healthy controls, the immune response was activated in asymptomatic patients, but was disturbed to varying degrees in mild to moderate and severe patients, and the turning point of changes in immune response was the change in neutrophil function.
.
In addition, the recovered patients showed significant immunosuppression, which persisted until 12 months after recovery
.
This study shows that long-term dysregulation of immune response, cholesterol metabolism and cardiovascular function may be the key triggers for the occurrence of potential sequelae.
The relevant research results comprehensively reveal the immune molecular map of different stages of COVID-19, which will help further exploration in the future to effectively improve complex diseases Early intervention strategies for sequelae
.
Based on the serum and urine proteomic data with ultra-high identification depth and accuracy, this study provides reliable and important molecular basis and mechanism information for comprehensive exploration of the prognosis evaluation of patients with new coronary pneumonia
.
Under the leadership of Professor Huang Chaolan, the Multi-omics Center has achieved a number of important achievements in the research of new crown scientific research based on the in-depth integration of clinical, cutting-edge technology and basic disciplines
.
Previously, the multi-omics center team led by Director Huang Chaolan worked closely with the multi-disciplinary team led by Academician Gao Fu and found that the early new coronavirus infection was mainly immunosuppressed and may have a "two-stage" mechanism1, and by describing the new crown spike protein sugar The new glycosylation pattern of "O-Follow-N" was revealed for the first time 2
.
In addition, consistent with the results of this study, Huang Chaolan's team also carried out a collaborative study with the team of Professor Zheng Min from the First Affiliated Hospital of Zhejiang University, focusing on the changes of serum protein expression in recovered patients with new coronary pneumonia for the first time, and proposed that recovered patients will still have cholesterol after 1 month Metabolic disorders and myocardial damage 3
.
Under the leadership of Professor Huang Chaolan, the multi-omics center team has always adhered to the origin of important scientific and clinical problems, developed innovative methods of mass spectrometry and proteomics, explored and revealed the unknown areas of life science, and obtained results that can contribute to life science.
and the real output of human health
.
Gao Fu, academician of the Chinese Academy of Sciences, Liu Jun, researcher of the Institute of Viral Diseases of the Chinese Center for Disease Control and Prevention, and Huang Chaolan, director of the Precision Medicine Multi-Omics Research Center of Peking University School of Medicine, are the co-corresponding authors of the paper, and Chen Yang, associate researcher of the Precision Medicine Multi-omics Research Center, Peking University School of Medicine , Dr.
Zhang Nan, Dr.
Zhang Jie from the Institute of Viral Diseases of the Chinese Center for Disease Control and Prevention, Guo Jiangtao from the Precision Medicine Multi-omics Research Center of Peking University School of Medicine, and Dong Shaobo, a researcher from the Macheng Center for Disease Control and Prevention in Hubei Province, are the co-authors of the paper
.
Link to the original text: https:// Related Articles: 1.
Tian, WM et al.
Immune suppression in the early stage of COVID-19 disease.
Nat Commun 11 , doi:10.
1038/s41467-020-19706-9 (2020).
2.
Tian, WM et al.
O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule.
Cell Res 31, 1123-1125, doi:10.
1038/s41422-021-00545-2 (2021).
3.
Chen, Y.
et al.
Proteomic Analysis Identifies Prolonged Disturbances in Pathways Related to Cholesterol Metabolism and Myocardium Function in the COVID-19 Recovery Stage .
J Proteome Res 20, 3463-3474, doi:10.
1021/acs.
jproteome.
1c00054 (2021).
.
According to Worldometer real-time statistics, as of February 14, 2022, the number of newly confirmed cases in a single day in the world reached 1,531,001, and 6,383 new deaths were reported
.
Effective response to the epidemic requires not only preventive and therapeutic measures to improve the survival rate of patients, but also early intervention strategies to deal with the sequelae of patients
.
Recently, the team of Professor Huang Chaolan from the Precision Medicine Multi-Omics Research Center of Peking University School of Medicine, the team of Academician Gao Fu of the Chinese Academy of Sciences, and the team of researcher Liu Jun of the Institute of Virology of the Chinese Center for Disease Control and Prevention carried out cooperative research, based on the "asymptomatic, mild to moderate disease, Four cohorts of patients with COVID-19 who are "severe, recovered", through the integrated analysis of proteomic data and clinical data, found that the immune function of patients with COVID-19 has a "multi-stage" process of activation in the asymptomatic stage, suppression in the early stage, and abnormal activation in the later stage.
Altered neutrophil function may be a turning point in immune dysfunction
.
At the same time, immune dysfunction, cholesterol metabolism disorders, and impaired myocardial function have run through the occurrence and development of COVID-19
.
This finding has implications for the development of early intervention strategies to improve patient outcomes
.
The study, titled "Immune response pattern across the asymptomatic, symbolic and convalescent periods of COVID-19", was published in the journal BBA-Proteins and Proteomics and was selected to be featured as the journal's 2022 cover article
.
Fig.
Screenshot of the front page of BBA-Proteins and Proteomics The researchers performed quantitative proteomic analysis based on the DIA-PASEF method on serum and urine samples from patients with new coronary pneumonia at different stages of disease progression
.
The results showed that compared with healthy controls, the immune response was activated in asymptomatic patients, but was disturbed to varying degrees in mild to moderate and severe patients, and the turning point of changes in immune response was the change in neutrophil function.
.
In addition, the recovered patients showed significant immunosuppression, which persisted until 12 months after recovery
.
This study shows that long-term dysregulation of immune response, cholesterol metabolism and cardiovascular function may be the key triggers for the occurrence of potential sequelae.
The relevant research results comprehensively reveal the immune molecular map of different stages of COVID-19, which will help further exploration in the future to effectively improve complex diseases Early intervention strategies for sequelae
.
Based on the serum and urine proteomic data with ultra-high identification depth and accuracy, this study provides reliable and important molecular basis and mechanism information for comprehensive exploration of the prognosis evaluation of patients with new coronary pneumonia
.
Under the leadership of Professor Huang Chaolan, the Multi-omics Center has achieved a number of important achievements in the research of new crown scientific research based on the in-depth integration of clinical, cutting-edge technology and basic disciplines
.
Previously, the multi-omics center team led by Director Huang Chaolan worked closely with the multi-disciplinary team led by Academician Gao Fu and found that the early new coronavirus infection was mainly immunosuppressed and may have a "two-stage" mechanism1, and by describing the new crown spike protein sugar The new glycosylation pattern of "O-Follow-N" was revealed for the first time 2
.
In addition, consistent with the results of this study, Huang Chaolan's team also carried out a collaborative study with the team of Professor Zheng Min from the First Affiliated Hospital of Zhejiang University, focusing on the changes of serum protein expression in recovered patients with new coronary pneumonia for the first time, and proposed that recovered patients will still have cholesterol after 1 month Metabolic disorders and myocardial damage 3
.
Under the leadership of Professor Huang Chaolan, the multi-omics center team has always adhered to the origin of important scientific and clinical problems, developed innovative methods of mass spectrometry and proteomics, explored and revealed the unknown areas of life science, and obtained results that can contribute to life science.
and the real output of human health
.
Gao Fu, academician of the Chinese Academy of Sciences, Liu Jun, researcher of the Institute of Viral Diseases of the Chinese Center for Disease Control and Prevention, and Huang Chaolan, director of the Precision Medicine Multi-Omics Research Center of Peking University School of Medicine, are the co-corresponding authors of the paper, and Chen Yang, associate researcher of the Precision Medicine Multi-omics Research Center, Peking University School of Medicine , Dr.
Zhang Nan, Dr.
Zhang Jie from the Institute of Viral Diseases of the Chinese Center for Disease Control and Prevention, Guo Jiangtao from the Precision Medicine Multi-omics Research Center of Peking University School of Medicine, and Dong Shaobo, a researcher from the Macheng Center for Disease Control and Prevention in Hubei Province, are the co-authors of the paper
.
Link to the original text: https:// Related Articles: 1.
Tian, WM et al.
Immune suppression in the early stage of COVID-19 disease.
Nat Commun 11 , doi:10.
1038/s41467-020-19706-9 (2020).
2.
Tian, WM et al.
O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule.
Cell Res 31, 1123-1125, doi:10.
1038/s41422-021-00545-2 (2021).
3.
Chen, Y.
et al.
Proteomic Analysis Identifies Prolonged Disturbances in Pathways Related to Cholesterol Metabolism and Myocardium Function in the COVID-19 Recovery Stage .
J Proteome Res 20, 3463-3474, doi:10.
1021/acs.
jproteome.
1c00054 (2021).
