First pan-cancer genomic analysis: Thousands of childhood cancers have been detailed at the genomic and molecular levels.

In two articles published online in the British journal Nature, Scientists in the United States and Europe detailed the representation of thousands of cases of childhood cancer at the genomic and molecular levels, the first pan-cancer genome analysis in children.
results help people understand the causes of childhood cancer and help develop new treatment options.
a team of scientists at the Hope Children's Cancer Center (KiTZ) at the NCT Heidelberg in Germany, 914 children with 24 different types of cancer at the molecular level were selected to identify different genetic changes.
types of cancer include the most common and clinically important cancers available, and tumors in the central nervous system are also in the focus.
researchers found genetic mutations in the repair of DNA double-stranded fractures in all cancer types.
7% of patients carry a disease-causing mutation in a cancer susceptibility candidate gene.
half of the tumors contain mutations that correspond to or exist, or are under development.
team at St. Jude Children's Research Hospital in the United States carried out further research based on these findings, focusing not only on DNA but also on analyzing its transcriptions.
they analyzed DNA changes and sequenced the genomes, exosomes and transcriptions of 1,699 cases of pediatric leukemia and solid tumors.
team identified 142 genes associated with cancer in these children, only 45 percent of which were consistent with findings in similar adult cancer studies.
researchers also found 11 mutation spands (regions where the mutation process left special marks in the genome), one of which was caused by exposure to ultraviolet light.
these studies offer new hope that drugs are available for treatment in some targets.
but at the same time, studies have revealed that childhood cancers are very different from their adult cancers, which must be taken into account when developing new treatments.
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