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Scientists at Cancer Research UK have used imaging as a new way to determine whether patients may benefit from certain breast cancer treatments, according to a study published in Cancer Target.
team at Royal College London teamed up with scientists at the Oxford Institute of Radiological Oncology to use fluorescent life imaging to determine if they were connected together.
fluorescence life imaging is a new technique that accurately measures the distance between two protein molecules.
in the study, the researchers measured the distance between THE two proteins, HER2 and HER3, from the patient's breast cancer cells.
the researchers believe that patients whose imaging results show that these proteins are already connected could benefit from HER2 targeted therapy, regardless of whether their tumors have a higher level of HER2.
HER2 is a protein that causes cancer cells to grow.
a higher level of this protein in HER2-positive breast cancer cells, which are targeted as drug action, blocking its effects and preventing cancer cells from growing, and currently used drugs such as Herceptin and Rapatinib.
patients benefit from these drugs, mainly by detecting high levels of HER2 protein in cancer cells.
however, in patients who responded better to HER2-targeted drugs, the imaging technique, which was performed in tumor cells, may have access to information about other proteins.
this technique can also determine which patients may not be suitable for these treatments.
Professor Tony Ng, of Royal College London, said: "This imaging technology helps us determine which patients will benefit from these drugs and have been ignored before.
"Applying this test we should be able to predict which drugs will not work in patients, thus avoiding unnecessary treatments--- allowing us to better apply them.
next step is to conduct clinical trials to see if the test can help patients. "We hope that one day we will not only improve the treatment of breast cancer, but also other cancers, including bowel and lung cancer."
Nell Barrie, of Cancer Research UK,
, said: "There are more than 50,000 new breast cancer patients every year, but thanks to new research, more people are surviving this disease than ever before.
the study may eventually provide doctors with another personalized treatment so that patients receive medication that is more likely to help them.
" Source: Decoding Medicine.