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    Home > Agriculture News > Pesticide News > Fluoxastrobin patent expires in January 2017? Its market competition will become more intense

    Fluoxastrobin patent expires in January 2017? Its market competition will become more intense

    • Last Update: 2022-03-08
    • Source: Internet
    • Author: User
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    Methoxyacrylic fungicides came from behind, becoming the world's largest type of fungicides surpassing triazoles
    .
    Azoxystrobin, pyraclostrobin, trifloxystrobin, picoxystrobin, fluoxastrobin and kresoxim-methyl are among the top six products in this category with sales of over 100 million U.
    S.
    dollars
    .
    Among them, fluoxastrobin was the latest on the market, and its compound patent has just expired on January 14, 2017
    .
    In the market environment where fluoxastrobin is located, "there are masters in the front", azoxystrobin and pyraclostrobin are far ahead: "there are chasing after", and the market for some newly launched products is growing rapidly
    .
    Especially now that the compound patent of fluoxastrobin has expired, how can it stand out in the fierce market competition? "Differentiation" is still an important breakthrough
    .
    The two major markets of crops and non-crops, rapid absorption, resistance to rain erosion, and crop health have become an important cornerstone for fluoxastrobin to create "differentiation"
    .
    With the joint efforts of Bayer, Arysta and Formosa, fluoxastrobin has been registered on more than 40 crops in more than 30 countries around the world, preventing more than 100 fungal diseases, and its annual sales exceeded 200 million.
    The US dollar has become another heavyweight product in the world
    .
    Fluoxastrobin English common name: fluoxastrobin; chemical name: (E)-{2-[6-(2-chlorophenoxy)-5-fluoropyrimidin-4-yloxy]phenyl}(5,6- Dihydro-1,4,2-Dioxazin-3-yl) ketone O-methyl oxime; molecular formula: C21H16ClFN4O5; relative molecular mass: 458.
    8; CAS registration number: [361377-29-9] (E-body ), [193740-76-0] (Mixture of E-body and Z-body); Development code: HEC 5725, BAY HEC 5725.
    Its chemical structure is shown in Figure 1.
    The product has obvious advantages and prominent health effects.
    Fluoxastrobin is The third-generation methoxy acrylate fungicide discovered and developed by Bayer CropScience
    .
    Discovered by Bayer in 1994; first reported by Collins and others in 1999; introduced by S.
    Dutzmann and others at the Brighton Plant Protection Conference in the United Kingdom in 2002; first entered the major European markets in 2004; produced by Bayer CropScience; now by Ai Lister, Bayer, and Formosa are jointly developed
    .
    Fluoxastrobin is an inhibitor of mitochondrial respiration.
    It prevents the electron transfer between bc1 by binding to the Qo site of cytochrome b in the bc1 complex III, thereby interfering with the fungus by preventing the production of energy (ATP) required by the cell The internal energy cycle eventually leads to cell death
    .
    The International Fungicide Resistance Action Committee (FRAC) divides it into: 11 categories, C3: QoI (Qo inhibitor), dihydrodioxazines
    .
    The selective part for crops is derived from the deesterification of enzymes in crops.
    The agent will not reach the mitochondria of animals and plants, and is safe for crops
    .
    Fluoxastrobin is a new systemic fungicide with protective and therapeutic effects
    .
    Under the same conditions, fluoxastrobin is superior to similar products such as azoxystrobin, trifloxystrobin and pyraclostrobin in leaf penetration, cross-layer conduction and xylem conduction
    .
    Fluoxastrobin can be quickly absorbed by plants, and evenly distributed throughout the plant by apical transmission, preventing the invasion of pathogens and improving plant immunity
    .
    At the same time, fluoxastrobin has the dual characteristics of contact killing and lasting effect
    .
    The test results show that 15 minutes after foliar application, fluoxastrobin can penetrate the waxy layer; 6 hours after the application, it reaches the leaf tissue; 9 hours after the application, it redistributes in the xylem; the non-application area It can also be well protected
    .
    Fluoxastrobin has good resistance to rain erosion
    .
    The product can well balance fat solubility and water solubility.
    Laboratory tests show that fluoxastrobin is effectively absorbed by plants 15 minutes after application
    .
    Fluoxastrobin has a broad control spectrum and can prevent diseases caused by pathogenic bacteria such as oomycetes, ascomycetes, deuteromycetes and basidiomycetes.

    .
    Such as Pythium, late blight, and downy mildew in Oomycetes; powdery mildew, white mildew, and sclerotium in ascomycete diseases; brown spot, large and small spot, etc.
    in imperfect fungus diseases Gray spot, anthracnose, Cercospora, etc.
    ; Rhizoctonia, rust, etc.
    in Basidiomycetes
    .
    Fluoxastrobin is applicable to many crops.
    Its global registered crops include: cucumber, artichoke, barley, persimmon, blueberry, cassava, celery, pepper, kale, corn, cranberry, cucumber, gourd, eggplant, ginger, grapes, mango, onion, ornamental plants, peanuts, pears, potatoes, pumpkin, rhubarb, rice, shallots, soybeans, squash, strawberries, sugar cane, sweet potatoes, Swiss chard, tomatoes, turf, wheat and yam and so on
    .
    Its main application crops include: barley, wheat, cereals, citrus, coffee, corn, cotton, ornamental plants, peanuts, peppers, potatoes, soybeans, strawberries, tobacco, tomatoes, lawns and vegetables
    .
    Fluoxastrobin has a wide application period.
    It can provide very good protection and treatment in the early stage of fungal infection, such as spore germination, germ tube growth, and leaf invasion, or in the hyphae growth period.
    The initial infection is most effective
    .
    Fluoxastrobin is widely used in stem and leaf spray, seed treatment and soil treatment
    .
    Among them, it is mainly used for stem and leaf treatment with a dosage of 75-200 g ai/hm2; it can also be used as a seed treatment agent with a dosage of 5-10 g/100 kg of seeds
    .
    Fluoxastrobin has excellent control effects on coffee rust, early potato blight and vegetable leaf spot
    .
    It has a very good effect on wheat leaf diseases, especially wheat leaf blight.
    It is said to be more effective than all other methoxy acrylate fungicides except pyraclostrobin
    .
    Field efficacy test results show that fluoxastrobin's control effects against wheat leaf blight, glume blight and rust, barley moire, stripe and rust have reached or exceeded the current best commercially available varieties of azoxystrobin.

    .
    From 2013 to 2014, the field efficacy test results of new fungicides in China showed that Arysta 660 g/L fluoropyrimidine
    .
    Chlorothalonil suspension agent has a good control effect on cucumber downy mildew and tomato late blight
    .
    The control effect of cucumber downy mildew can reach 98.
    5%, and the highest control effect of tomato late blight is 80.
    9%.
    It is suitable for use before or at the beginning of the onset, with an interval of 7 days, spraying 2 to 3 times, and spray evenly
    .
    It is safe for cucumber and tomato at the test dose
    .
    Fluoxastrobin also has outstanding plant health effects
    .
    The product mainly delays plant senescence by affecting various physiological processes in the plant, making plants greener and filling more fully; enhancing crop resistance to harsh environments and maintaining healthy growth; improving crop quality and increasing crop yield
    .
    These effects on plant physiological processes include: reducing the production of ethylene, increasing the efficiency of carbon assimilation, increasing nitrogen fixation, increasing water utilization, and improving nutrient absorption and utilization
    .
    Many companies have joined to expand the market together.
    The long-term cooperation must be divided, and the long-term division must be combined.
    The same is true for the merger and reorganization of pesticide companies
    .
    Since fluoxastrobin involves many companies participating in the development, it is necessary to explain it first
    .
    After the American Platform Specialty Products acquired the Belgian Agrochemical Company (Agriphar) in October 2014, the American Cozua Company in November 2014, and the acquisition of Arysta Life Sciences and other companies in February 2015, the former US Four companies including Arysta, French Gomer Bioactivator, former American Cojuya Agrochemicals, and former European Belgian Agrochemicals merged to form New Arysta
    .
    Therefore, since 2015, the connotation of Arysta has been different from what it used to be
    .
    In April 2015, Formica completed the acquisition of Keminong, thus becoming a truly global agrochemical company
    .
    Therefore, Fumeshi and Comernon have naturally become a family since 2015
    .
    As mentioned above, Bayer discovered, developed and produced fluoxastrobin.
    Perhaps because Bayer acquired trifloxystrobin from Syngenta, in order to avoid excessive overlap in the market, Bayer eliminated fluoxastrobin.
    Most rights are granted to Arysta
    .
    However, so far, Bayer still occupies most of the market share of fluoxastrobin
    .
    In 2005, Bayer granted Arysta Life Sciences the right to develop and sell fluoxastrobin
    .
    According to this, Arysta can sell fluoxastrobin in the United States, Japan and Canada for use in crops; it can also sell fluoxastrobin globally for use in non-crop fields
    .
    In 2012, Arysta and Bayer signed another agreement.
    According to this agreement, Arysta has the exclusive right to sell fluoxastrobin in crop and non-crop fields, but Bayer still retains fluoxastrobin.
    The right to develop and sell strobilurin seed treatment agent and some special compound products
    .
    Arysta has successfully developed two brand products of fluoxastrobin, Evito and Disarm (both are 480 g/L fluoxastrobin suspension)
    .
    Evito is used for food crops, and Disarm is used for lawns
    .
    On this basis, the company plans to make full use of existing products while continuously developing new markets for fluoxastrobin in its six global business areas
    .
    Alista pointed out that fluoxastrobin is a multifunctional fungicide, which is of great significance to growers
    .
    It can provide a broad-spectrum disease prevention and control effect, and exhibits excellent health care functions
    .
    In 2013, Arysta and Comernon reached an agreement to jointly sell the fungicide Fortix (fluoxastrobin + fluconazole) in the United States for use in corn and soybeans
    .
    In 2013, Italian SEG and Arysta signed a 15-year licensing, development, distribution and supply agreement
    .
    According to the agreement, Arysta has obtained the exclusive global development rights for the combined products of tetraflurane (Italian SAG) and fluoxastrobin for use in all agricultural markets
    .
    In 2014, Arysta Life Sciences North America signed an exclusive license agreement with Formosa.
    Formosa was able to develop and sell Arysta Disarm (fluoxastrobin) and the herbicide Xonerate (acarbazone) in the United States and Canada.
    ), used for lawns and ornamental plants
    .
    As a result, when fluoxastrobin is still under patent protection, many development companies have been deployed in the market
    .
    Under the joint operation of these multinational companies, the sales performance of fluoxastrobin has lived up to expectations
    .
    In 2009, the sales of fluoxastrobin were US$150 million; the compound annual growth rate from 2004 to 2009 was as high as 71.
    9%, which was the highest compound annual growth rate among the 12 methoxyacrylate fungicides on the market during the period.
    Variety
    .
    In 2010, fluoxastrobin sales were 140 million U.
    S.
    dollars.
    Although down 6.
    7% year-on-year, the compound annual growth rate from 2005 to 2010 was still as high as 47.
    6%.
    In 2011, fluoxastrobin sales were 1.
    75 Billion US dollars, a year-on-year increase of 25.
    0%; of which, Bayer was 160 million US dollars, accounting for 91.
    43%; the other 15 million US dollars, accounting for 8.
    57%.
    In 2012, the sales of fluoxastrobin decreased by 5.
    7% from the previous year to 165 million US dollars
    .
    In 2014, thanks to the successful development of prothioconazole seed treatment compound products, the global sales of fluoxastrobin soared to 220 million U.
    S.
    dollars; the compound annual growth rate from 2009 to 2014 was 8.
    0%; among them, Bayer's global sales of fluoxastrobin were US$180 million in 2014, still occupying more than 80% of the global market
    .
    In 2015, the global sales of fluoxastrobin was US$200 million, a year-on-year decrease of 9.
    1%, which is in line with the trend of the global pesticide market; from 2010 to 2015, the compound annual growth rate of fluoxastrobin was 7.
    4%.
    Registration Orderly advancement, the market continues to expand.
    In the methoxy acrylate fungicides market, fluoxastrobin has many "predecessors" who are world-class "models", and the global market for azoxystrobin has even exceeded 1.
    300 billion US dollars.

    .
    Fluoxastrobin has gone through more than twelve years in such a market encounter, and has been registered in more than 30 countries around the world for use on more than 40 crops, preventing more than 100 diseases, and harvesting US$200 million in global sales.

    .
    Fluoxastrobin was first registered in the UK in 2004; in the same year, Bayer launched Fandango (100 g/L fluoxastrobin + 100 g/L prothioconazole, EC) for use in cereals
    .
    In 2005, Bayer launched the seed treatment agent Redigo Twin (prothioconazole + fluoxastrobin) in the UK for wheat; in the same year, fluoxastrobin was marketed in Germany for grains under the trade name Fandango.
    2005 On September 20, 95.
    8% fluoxastrobin technical and 480 g/L fluoxastrobin SC were registered in the United States
    .
    The 10-year registration data protection period is until September 19, 2015
    .
    In 2006, fluoxastrobin was marketed in the United States for use in crops such as celery, ornamental plants, peanuts, peppers, potatoes, tomatoes and tobacco under the trade name Evito; in the same year, it was marketed in the United States for lawn use under the trade name Disarm.
    In 2006, Fandango was registered in France for use in grains; it was launched in France in the spring of 2007
    .
    In 2006, Bayer launched EFA (prothioconazole + fluoxastrobin + tebuconazole + imidazosin) for grain seed treatment in Germany
    .
    In 2007, Bayer registered Vigold 480 SC in Mexico.
    On August 1, 2008, fluoxastrobin was officially registered in the EU and was included in the EU Pesticide Registration Regulation (1107/2009) as a new active ingredient.
    , Its registration data is protected until July 31, 2018
    .
    The United Kingdom is the country that drafted fluoxastrobin registration documents in the EU
    .
    Fluoxastrobin is registered in the EU for use in wheat, rye, and barley to prevent rust, leaf spot, net spot, powdery mildew, and diseases caused by Septoria spp
    .
    The preparation product is 100 g/L EC, the dosage is 0.
    1~0.
    2 kg/hm2, the water consumption is 200~400 L/hm2, and the safety interval is 35 d.
    On June 18, 2009, Arysta North America Branch was in the United States Registered for Disarm M (15.
    81% fluoxastrobin + 25.
    6% myclobutanil; SC)
    .
    In 2009, Bayer's composite product Scenic (37.
    5 g/L fluoxastrobin + 37.
    5 g/L prothioconazole + 5 g/L tebuconazole) was registered in Italy for the control of wheat There are diseases caused by Fusarium spp.
    , wheat bunt (Tilletia caries), wheat bunt (Tilletia tritici) and oat spot blight (Pyrenophora avenae)
    .
    In 2011, Bayer launched Scenic (fluoxastrobin + prothioconazole + tebuconazole) for wheat seed treatment in Argentina
    .
    In 2012, the Canadian Pest Management Agency (PMRA) approved the registration of Arysta’s fluoxastrobin product Evito 480 SC (480 g/L) for use in corn, wheat, barley, soybeans, potatoes, tomatoes, peppers, strawberries and lawn
    .
    The product can be used for prevention and treatment of many diseases, such as cereal rust and powdery mildew, potato late blight
    .
    In 2013, fluoxastrobin launched fluoxastrobin product Evito T (fluoxastrobin + tebuconazole) in Zambia and Mozambique for use in corn, soybeans, sugar cane, wheat, tomatoes and potatoes
    .
    Fluoxastrobin has since entered the African market
    .
    In 2013, Arysta Life Sciences North America reached an agreement with Comernon to jointly sell the new fungicide Fortix (167 g/L fluoxastrobin + 218 g/L flutriazole) in the United States for use in corn and soybeans
    .
    Fortix is ​​a compound product of Arysta's fluoxastrobin and Comacon's flutriazol, which can prevent and control soybean and corn diseases throughout the season
    .
    In early 2015, Fortix was approved to register for winter wheat and spring wheat in the United States
    .
    Wheat is the third major crop registered by Fortix.
    Using Fortix at the flag leaf stage of wheat can effectively control and prevent a variety of diseases, such as leaf rust, stripe rust, stem rust, powdery mildew, spot blight, glume blight and Brown spot disease and so on
    .
    The two companies will also expand Fortix to other crops, such as sugarcane, etc.

    .
    In 2013, Italian SEG and Arysta signed a 15-year license, development, distribution and supply agreement
    .
    According to the agreement, Arysta has obtained the exclusive global development rights for the combined products of tetraflurane (Italian SAG) and fluoxastrobin for use in all agricultural markets
    .
    In 2014, Arysta Life Sciences North America signed an exclusive license agreement with Formosa.
    As a result, Formosa was able to develop and sell Arysta Disarm (fluoxastrobin) and the herbicide Xonerate (amicarbazone) in the United States and Canada.
    ), used for lawns and ornamental plants
    .
    The disinfectant Disarm product series includes 4 dosage forms, each of which is tailored to suit specific regional climates, diseases and lawn types
    .
    Disarm can be used alone or as a premix for chlorothalonil or DMI-based products
    .
    In 2014, Arysta launched ViGold-T (fluoxastrobin + tebuconazole) in Indonesia for use in rice and vegetables
    .
    Arysta hopes to register the product in all major rice and vegetable growing countries in Asia
    .
    ViGold-T has an excellent performance in the field.
    It can promote the neatness of the rice ears during the rice filling period and make the flag leaves stay green for a longer time
    .
    Compared with other fungicides, ViGold-T can ensure a more effective grouting, which results in better rice quality
    .
    In 2015, Fumashi launched its lawn fungicide Fame (fluoxastrobin).
    This product has a fast onset of action and is absorbed by the leaves and roots.
    It can be used on all types of golf lawns to prevent and control all major spots and mildews.

    .
    At present, the Fame fungicide series products include: Fame SC; Fame Granular; Fame+C (fluoxastrobin + chlorothalonil), which has a broad control spectrum and can prevent more than 30 diseases including anthracnose and brown spot; Fame + T (fluoxastrobin + tebuconazole), which combines two mechanisms of action to optimize resistance management
    .
    Tests have shown that Fame+T can protect root and seedling diseases, including currency spot, snow mold, spring dead spot and major spot diseases, etc.

    .
    At the end of 2015, Arysta launched Zolera FX (fluoxastrobin + tetrafluraneconazole) in North America
    .
    Zolera FX has good systemic properties, high activity, broad spectrum, and has a strong crop health effect, which can increase the yield of corn and soybeans
    .
    Tests have proved that Zolera FX has excellent performance in the VT stage of corn growth; it has a very good effect on soybeans, especially in the prevention and control of soybean white mold
    .
    In 2016, Arysta registered Evito T (fluoxastrobin + tebuconazole) in Ukraine for use in cereals and rape
    .
    On June 20, 2016, Bayer AG temporarily registered 94% fluoxastrobin technical in China
    .
    On June 22, 2016, Arysta Life Sciences Co.
    , Ltd.
    temporarily registered 51% fluoropyrimidine in China
    .
    Chlorothalonil suspension (4.
    6% fluoxastrobin + 46.
    4% chlorothalonil)
    .
    On September 18, 2016, the two products were officially registered in China
    .
    51% fluoropyrimidine
    .
    The commercial name of Chlorothalonil Suspension Concentrate is "Yiweidole".
    It is sprayed to prevent tomato late blight and cucumber downy mildew.
    The effective ingredient dosage is 990-1,320 g/hm2.
    Both products are low-toxic
    .
    At the beginning of 2017, two new products of Arysta Life Sciences North America: the fungicide/insecticide Tepera Plus (fluoxastrobin + bifenthrin) and the fungicide Tepera (fluoxastrobin), won the US environmental protection Department’s registration for corn and soybeans
    .
    Both products use patented processing technology, so that they can be applied together with liquid fertilizer in furrows without the need for dilution or the use of special equipment
    .
    The two products are easy to use, not only provide plant health effects, but also can effectively prevent seed and soil-borne diseases on corn and soybeans.
    Tepera Plus can also prevent and control pests (such as corn rootworm larvae, golden needle insects, corn maggots, grubs and cutworms).
    Etc.
    ), protecting seeds and crops from planting to harvesting, which can significantly increase crop yields
    .
    The two products will also be registered on other crops in the future
    .
    In 2016, corn field trials showed that after the application of Tepera Plus and Tepera, the plants were taller, sturdier, and had full ears.
    Compared with the control, the average yield per acre increased by 14.
    2 bushels
    .
    Similarly, field trials on soybeans showed an average yield increase of 7.
    9 bushels compared to the control
    .
    On March 16, 2017, Arysta launched the Evadole (51% fluoropyrimidine
    .
    Chlorothalonil suspension) launch meeting in China, marking that Evadole will be fully listed in China
    .
    Yiweidole has a good effect on disease prevention and control, and can promote plant health, improve crop quality and increase crop yield, and achieve increased production and income
    .
    As of March 11, 2017, fluoxastrobin has been registered in 17 EU countries, and 4 other countries are in the process of registration
    .
    The 17 countries that have been registered are: Austria, Belgium, the Czech Republic, Germany, Estonia, EL, Spain, France, Ireland, Italy, Lithuania, Luxembourg, Latvia, the Netherlands, Poland, Slovakia, and the United Kingdom; the 4 countries that are currently being registered are: Finland, Hungary, Sweden, Slovenia
    .
    In addition to European Union 17, fluoxastrobin is registered and marketed globally in countries including the United States, Canada, Argentina, China, Indonesia, Japan, Mexico, Mozambique, Zambia, Switzerland, and New Zealand, etc.

    .
    There are many compound products of fluoxastrobin.
    Its main compatible products can be summarized as: Prothioconazole (Bayer, trade name Bariton, Fandango, Firefly, Maestro, Toledo; seed treatment agent, trade name Redigo Twin), Prothioconazole Azole + tebuconazole (Bayer, seed treatment agent, trade name Scenic, Bayazzo), prothioconazole + tebuconazole + imidazosin (Bayer, seed treatment agent, trade name EFA), prothioconazole + trifloxystrobin (Bayer, trade name Jaunt), flutriazol (Allistar, Komainon, trade name Fortix), pentosalon (Bayer, trade name Subliem), bifenpyramide + prothioconazole (Bayer, Trade name Variano Xpro), Tetraflurane azole (Allistar, Trade name Zolera FX), Chlorothalonil (Allistar, Fumex, trade name Fame+C, Evadole), Tebuconazole (Fumex, trade name Fame + T), bifenthrin (Ailisida, trade name Tepera Plus) and so on
    .
    The patent has expired, and field trials are active in January 2017, which is an important node in the history of fluoxastrobin development.
    Its compound patents in major global markets have expired
    .
    On January 14, 2017, the patent of fluoxastrobin in China, Europe and the world expired; on January 15, 2017, its patent in the United States expired
    .
    On September 19, 2015, the registration data protection period of fluoxastrobin in the United States expired; its registration data in the European Union was protected until July 31, 2018
    .
    PCT/European Patent: Compound Patent (Bayer CropScience Company; Halogen pyrimidines and its use thereof as parasite abatement means, halogenated pyrimidines and their application as a method for reducing parasites), EP0882043, WO9727189, two patents filed in 19971 On 15th, the term of protection was until January 14, 2017; the European patent EP0882043 obtained the UK Supplementary Protection Certificate (SPC): SPC/GB05/001, and the term of protection was extended to August 16, 2019
    .
    Several compound products of fluoxastrobin have also obtained SPC protection
    .
    These products include: bixafen + fluoxastrobin + prothioconazole, with the longest protection period of SPC until January 21, 2026; fluopyram + fluoxastrobin + prothioconazole + tebuconazole Alcohol, the longest protection period of SPC is until August 27, 2027; fluoxastrobin + penesulfuron, SPC protection until November 26, 2022; fluoxastrobin + prothioconazole, the longest protection period of SPC is 2022 December 17th
    .
    U.
    S.
    Patent: Compound patent (Bayer Crop Science; Halogen pyrimidines and its use thereof as parasite abatement means, halogenated pyrimidines and their application as parasite reduction methods), US6407233, this patent was applied for on January 15, 1997, Ended on January 15, 2017
    .
    Chinese patent: compound patent (Bayer; halogenated pyrimidines, their preparation methods and pesticides containing them), CN1072223C, which was applied for on January 15, 1997 and expired on January 14, 2017
    .
    With the expiration of the compound patent of fluoxastrobin, domestic companies have also started the registration and listing of the product
    .
    In addition to Arysta, nearly 10 domestic companies have conducted field trials of fluoxastrobin products
    .
    As of March 6, 2017, there are 18 fluoxastrobin products that have been approved for field trials in China and are within the validity period
    .
    Among them, there are 5 single doses and 13 compound products
    .
    Compatibility products: tebuconazole, difenoconazole cyproconazole, prothioconazole, Shenqinmycin dimethomorph and the like
    .
    The dosage forms are suspension concentrates and emulsifiable concentrates
    .
    These products are mainly used for cucumber, banana, wheat and rice, etc.
    , to prevent powdery mildew, leaf spot, rust, rice smut, rice blast, sheath blight and downy mildew, etc.

    .
    Explore product potential and break out of market differences.
    As for fluoxastrobin, there are already many companies involved in market development; when its patent protection in China and the world expires, too many companies are eager to try, and the future market competition for fluoxastrobin is destined Intense, just like other blockbuster products
    .
    It is not difficult to find that when Bayer transferred most of the rights of fluoxastrobin to Arysta, it also left a tail for itself
    .
    This tail market includes the seed treatment of fluoxastrobin and Bayer's patented compound products.
    With this seemingly "tail" market, Bayer occupies about 80% of fluoxastrobin
    .
    Seed treatment is certainly part of differentiation, however, patented products endow differentiation with greater market competitiveness and become an insurmountable threshold for ordinary products
    .
    In particular, Fandango, a compound product of fluoxastrobin and prothioconazole, has become one of the important brands successfully created by Bayer
    .
    Today, the succinate dehydrogenase inhibitor (SDHI) fungicides, bixafen and fluopyram, have also been added to the list of fluoxastrobin compound products.
    Its Xpro product is another important brand of Bayer.

    .
    In the cereal market, fluoxastrobin encounters fierce competition from similar or dissimilar products
    .
    However, one of Arysta’s launch strategies is to develop non-crop markets for fluoxastrobin, such as lawns and ornamental plants
    .
    At present, Arysta has launched the Disarm brand series for lawns, which has achieved success in the North American non-crop market
    .
    The unique market launch creates a blue ocean for fluoxastrobin
    .
    Coffee is another distinctive crop sector of fluoxastrobin, which makes fluoxastrobin more acceptable in South America.
    This is a natural advantage that other methacrylate products do not have
    .
    Of course, fluoxastrobin also has a layout on many other crops
    .
    Arysta uses meticulous market planning to give full play to the potential of its products, thereby continuously increasing its weight in the global market of fluoxastrobin
    .
    Fluoxastrobin has excellent systemic properties, broad bactericidal spectrum, both protection and treatment of crops, complete contact and lasting activities, and outstanding "plant health effects".
    It can be used in crop and non-crop fields
    .
    Under the joint cultivation of companies such as Arysta, Bayer and Formosa, its sales have risen steadily and have reached the market level of US$200 million.
    There is still room for growth in the future market
    .
    ? Figure 1? The structural formula of fluoxastrobin? Table 1? The global sales of fluoxastrobin? Time (years)? Sales (100 million US dollars)? Year-on-year? 2004? 0.
    101??? 2005? 0.
    202??? 2009 ? 1.

    .
    ?? Figure 2? 2010-2015 global sales of fluoxastrobin (millions of US dollars)?? Table 2? Fluoxastrobin products approved for field trials in my country? Active ingredients and content? Formulation name? Crop? Control Who? Company name? 25% tebuconazole + 18% fluoxastrobin? SC? Cucumber? Powdery mildew? Arysta Biochemical North America Co.
    , Ltd.
    ? 20% difenoconazole + 20% fluoxastrobin ?
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