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Follow-up of 10,000 people for more than 30 years: there are three high-level chronic diseases in middle age, and the risk of dementia in later life is nearly 5 times higher!

 Last Update: 2022-04-16
 Source: Internet
 Author: User

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The increase in human life expectancy over the past two centuries means that adults often live to age 65 or more, especially in high-income countries

Several comorbidities are common in Alzheimer's patients

In this prospective cohort study, investigators included 10,095 participants with a baseline age of 35 to 55 years

During a median follow-up of 31.

In the individual chronic disease analysis ( Table 2 ), cancer (hazard ratio 1.

In an analysis that included adjustment for all covariates, multimorbidity (two or more of the 13 chronic diseases) at age 55 was associated with higher incidence compared with those without any of the 13 chronic diseases rate (difference 1.

(95% confidence interval 0.

Reclassification of polydisease according to severity (≤1, 2, ≥3 of the 13 chronic diseases; Figure 2) showed that compared with subjects with no or one chronic disease at age 55, subjects with three chronic diseases at age 55 The hazard ratio for dementia in subjects with chronic disease or more was 4.

Figure 3 shows an exploratory analysis of the association of chronic disease dyads with subsequent dementia treated as time-varying covariates

Overall, in this analysis of more than 10,000 people who were followed for more than 30 years, polydipsia (two or more chronic diseases) was associated with a higher risk of subsequent dementia

Overall, in this analysis of more than 10,000 people who were followed for more than 30 years, polydipsia (two or more chronic diseases) was associated with a higher risk of subsequent dementia
.
The strongest association was observed in patients with multi-morbidity at age 55 years, and the association with multi-morbidity weakened at older age
.
The importance of younger age of onset for dementia risk was further highlighted when polydipsia was defined as three or more chronic diseases
.
People with three or more chronic diseases at age 55 had nearly 5 times higher risk of developing dementia compared to people with no or only one chronic disease; increased risk when polydisease developed at age 70 1.
7 times
.
This study is the first to show that being sickly in midlife is associated with a higher risk of Alzheimer's disease
.
Overall, in this analysis of more than 10,000 people who were followed for more than 30 years, polydipsia (two or more chronic diseases) was associated with a higher risk of subsequent dementia
.
The strongest association was observed in patients with multi-morbidity at age 55 years, and the association with multi-morbidity weakened at older age
.
The importance of younger age of onset for dementia risk was further highlighted when polydipsia was defined as three or more chronic diseases
.
People with three or more chronic diseases at age 55 had nearly 5 times higher risk of developing dementia compared to people with no or only one chronic disease; increased risk when polydisease developed at age 70 1.
7 times
.
This study is the first to show that being sickly in midlife is associated with a higher risk of Alzheimer's disease
.

Given the lack of effective treatments for dementia and its personal and societal impact, finding targets for dementia prevention is imperative
.
Multi-morbidity is increasingly common, beginning in early and middle adulthood
.
The findings of the present study suggest that multiple diseases are associated with an increased risk of Alzheimer's disease, especially in middle-age rather than later-life onset
.
These findings underscore the role of chronic disease prevention and management in adulthood to mitigate adverse outcomes in old age
.
Multi-morbidity is known to affect use of healthcare services, quality of life, and risk of death
.
This study added dementia to this list
.
Multiple STDs are associated with an increased risk of Alzheimer's, especially in middle age rather than later in life
.
These findings underscore the role of chronic disease prevention and management in adulthood to mitigate adverse outcomes in old age
.
Especially when it occurs in middle age rather than later in life
.
included in this list
.

Original source:

Céline Ben Hassen, et al.
Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study.
BMJ 2022 ; 376 doi: https://doi.
org/10.
1136/bmj-2021 -068005 (Published 02 February 2022) Cite this as: BMJ 2022;376:e068005

Céline Ben Hassen, et al.
BMJ 2022 ; 376 doi: https://doi.
org/10.
1136/bmj-2021-068005 (Published 02 February 2022) BMJ 2022 376 doi: https://doi.
org/10.
1136/bmj -2021-068005 https://doi.
org/10.
1136/bmj-2021-068005 (Published 02 February 2022) Cite this as: BMJ 2022;376:e068005 BMJ commented

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