Determining a person's blood type based on genetic tests rather than traditional blood tests can better understand the risk of cardiovascular disease
.
If a patient has two a, B, or AB gene variants, the risk is twice that of one o gene variant
.
This is the discovery of a new study conducted by Uppsala University using data from the British Biobank
.
"There is a huge difference in the risk of blood clots, depending on if someone has a genetic variant of one or two blood types, AB or B.
Simply put, there are two risks of blood clots, if you have two variants a Or B, not just one," said Julia Hoglund, a doctoral student of immunology, professor of genetics and pathology at Uppsala University, and the first author of the study
.
A person may have one of four blood types: A, B, AB, or o
.
For example, when receiving a blood transfusion, a person's blood type is critical
.
Recent studies have shown that blood type plays an important role in viral and bacterial infections, and even in the occurrence of cardiovascular diseases and cancer
.
The currently published research shows that genetic variants that individuals obtain from their parents can also affect the risk of disease
.
This study is based on data from 500,000 subjects including the British Biobank
.
Researchers conducted a more in-depth analysis of the genetics behind blood types
.
Like previous studies, this study shows that people with blood type O have a lower risk of cardiovascular disease (such as blood clots) than people with other blood types
.
But by performing genetic analysis of blood types, rather than using traditional blood analysis (using antibody tests), researchers can determine which genetic variant a person has obtained from their parents
.
This has important implications in disease identification, blood type A because the individual may have one or two A-type O-type A and a genetic variation
.
"Because both a and B mask the O gene, they cannot be detected in routine blood tests
.
A person's genetic variation plays an important role in the risk of cardiovascular disease
.
If this is the standard method for patients, It will significantly improve the ability to detect high-risk patients," Höglund said
.
Another finding of this study is that researchers can see that people with different blood types have different levels of multiple proteins in their bodies
.
The most obvious example is the protein that helps blood clot
.
Blood types that increase the risk of blood clots also increase protein levels that are important for blood clotting
.
"Our research results show that by using the determination of the patient's blood type and blood type inheritance as the standard, we will be able to detect and start treatment of the disease at an early stage, which can prevent or delay serious complications
.
"
Original search:
Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank
