For every additional 10 μg/day, colorectal risk decreased by 8%!

For many years, colorectal cancer (CRC) has been ranked as one of the three cancers with the highest morbidity and mortality in high-income countries
.

The cancer burden results in approximately 1.

For many years, colorectal cancer (CRC) has been ranked as one of the three cancers with the highest morbidity and mortality in high-income countries

Selenium, an essential trace element found in Brazil nuts, fish, ham, meat, grains and pasta, is one of the dietary factors of concern
.

This element may prevent cancer by affecting the expression of genes Bcl-2 and p53, and by enhancing reactive oxygen species elimination and downregulation of interleukin-2, effects on intracellular signaling, activation of thyroid hormones, and enhanced apoptosis

It is one of the dietary factors that people pay attention to

This study aimed to estimate the odds ratio of colorectal cancer to dietary selenium content, and to further analyze the interaction between dietary selenium and dietary calcium, and to investigate colorectal colorectal in different subgroups characterized by different levels of selenium and calcium intake cancer odds ratio

In this study, 683 CRC cases and 759 controls were eligible for analysis
.

Significant differences observed between the two groups were: gender distribution, with more males in the CRC group (57% vs.

In this study, 683 CRC cases and 759 controls were eligible for analysis

The main question of the study was about the role of selenium in CRC
.

The estimated effect of dietary selenium intake (ie, every 10 μg increase per day) was associated with a 10–6% decrease in odds ratios, depending on the number of covariates considered (Table 2)

The main question of the study was about the role of selenium in CRC

Since the researchers assumed that the effects of selenium depend on calcium intake levels, two models were run to test the interaction term between selenium and calcium

Taken together, dietary selenium was associated with an 8% lower odds of colorectal cancer after adjustment for several covariates (OR = 0.

92, 95% CI: 0.
84-0.
99 per additional 10 μg selenium/day)

Taken together, this study demonstrates that dietary selenium has a beneficial effect on reducing the odds ratio of CRC in a low-intake population
.
The role of selenium has been altered by dietary calcium
.
Therefore, the present study provides some plausible evidence for an increase in subgroups with low intakes of selenium and calcium
.
Furthermore, the findings suggest the need for well-designed intervention studies, taking into account selenium and calcium status and intake in the intervention group, to validate their protective effects and interactions
.

 

Original source:

Augustyniak M, et al.
Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland.
BMC Nutr.
2022 Mar 14;8(1):22.
doi: 10.
1186/s40795-022- 00515-w.
PMID: 35287753; PMCID: PMC8919630.

60 to 80 μg/day and ≥80 μg/day decreased by 44% and 66%, respectively
.
Effects of dietary selenium improved by dietary calcium p <.
005>

Taken together, this study demonstrates that dietary selenium has a beneficial effect on reducing the odds ratio of CRC in a low-intake population
.
The role of selenium has been altered by dietary calcium
.
Therefore, the present study provides some plausible evidence for an increase in subgroups with low intakes of selenium and calcium
.
Furthermore, the findings suggest the need for well-designed intervention studies, taking into account selenium and calcium status and intake in the intervention group, to validate their protective effects and interactions
.

 

Original source:

Augustyniak M, et al.
Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland.
BMC Nutr.
2022 Mar 14;8(1):22.
doi: 10.
1186/s40795-022- 00515-w.
PMID: 35287753; PMCID: PMC8919630.

Taken together, this study demonstrates that dietary selenium has a beneficial effect on reducing the odds ratio of CRC in a low-intake population
.
The role of selenium has been altered by dietary calcium
.
Therefore, the present study provides some plausible evidence for an increase in subgroups with low intakes of selenium and calcium
.
Furthermore, the findings suggest the need for well-designed intervention studies, taking into account selenium and calcium status and intake in the intervention group, to validate their protective effects and interactions
.

Taken together, this study demonstrates that dietary selenium has a beneficial effect on reducing the odds ratio of CRC in a low-intake population
.
Dietary selenium had a beneficial effect of reducing the odds ratio of CRC in a low intake population
.
The role of selenium has been altered by dietary calcium
.
Therefore, the present study provides some plausible evidence for an increase in subgroups with low intakes of selenium and calcium
.
Furthermore, the findings suggest the need for well-designed intervention studies, taking into account selenium and calcium status and intake in the intervention group, to validate their protective effects and interactions
.

 

Original source:

Augustyniak M, et al.
Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland.
BMC Nutr.
2022 Mar 14;8(1):22.
doi: 10.
1186/s40795-022- 00515-w.
PMID: 35287753; PMCID: PMC8919630.

Augustyniak M, et al.
Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland.
BMC Nutr.
2022 Mar 14;8(1):22.
doi: 10.
1186/s40795-022- 00515-w.
PMID: 35287753; PMCID: PMC8919630.
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