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    Home > Medical News > Latest Medical News > For long-term use of metformin, please take this vitamin to prevent four discomforts

    For long-term use of metformin, please take this vitamin to prevent four discomforts

    • Last Update: 2020-06-26
    • Source: Internet
    • Author: User
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    Guide: Metformin is no stranger to diabeticsmetformin is a classic sugar-lowering drug that helps the body reduce the production of liver sugar, reduce the absorption of sugar in the intestines, and increase insulin-to-sugar usein general, this is a very effective anti-sugar drugsince the advent of, metformin with its price-friendly, good sugar control effect, high safety and other advantages, steady accounted for the type 2 diabetes preferred full drug use of the "throne."but "is a drug three-point poison", metformin, although safe and effective, but long-term use will also have side effects, such as affecting the body's absorption of vitamin B12why does metformin affect the absorption of vitamin B12? What symptoms appear when taking the drug indicate a deficiency in vitamin B12? How do i add it?Why do you need vitamin B12 supplementationtaking metformin for a long time?studies show editing that in diabetics who take metformin, 30% of patients have a lower absorption of vitamin B12 and 5% to 10% of patients have a lower serum vitamin B12the mechanism ofmetformin leading to low serum vitamin B12 levels is not clear, but it is widely recognized that the following three are:(1) metformin will slow down the rate of peristalcation of the gastrointestinal tract, change the structure of the intestinal tract, resulting in a larger number of intestinal flora, competitive inhibition of vitamin B12 absorption;(2) changes in the level of factors in vitamin B12 and the interaction of cobalamin intradonia receptors;(3) after taking metformin, the cell membrane activity of calcium dependence at the end of the intestinal tract will be affected, vitamin B12 depends on calcium binding, and then absorbed at the end of the intestinal tract, if the cell membrane at the end of the intestinal tract is damaged, it will affect the absorption of vitamin B12This inhibition can be reversed by calcium supplementationWhat are the symptoms of vitamin B12 deficiency indiabetics?1Regular hand and foot hairvitamin B12 can help the body to produce myelin, lack of vitamin B12 can lead to peripheral neuropathyif the lack of vitamin B12, the body myelin will be reduced, the nervous system is prone to damage, the nerves of the hands and feet will also be damaged, the appearance of numbness and tingling2Itchy or tingling of the tongue, white tonguelack of vitamin B12, nervous system is susceptible to anaemia, gums and tongue are prone to whitening, but also tingling and itchy feelings3Often restless, difficult to concentrate, memory lossvitamin B12 contains dopamine and serotonin substances, can participate in the synthesis of brain chemicals, thereby maintaining and regulating moodlack of vitamin B12 can damage the motor nerves of the brainAnxiety, depression, irritability, difficulty concentrating, and memory loss are common4Anemia, pale, small white spots on the skinvitamin B12 can promote red blood cell maturation and maintain the body's hematopoietic function if the lack of vitamin B12, there will be anemia, pale, skin long white spots, women, menstruation will also reduce note: to determine whether vitamin B12 is lack of vitamin, need to go to the hospital to check the serum vitamin B12 content when the concentration of serum vitamin B12 is less than 100 ?g/ml, vitamin B12 deficiency can be diagnosed (normal value is 100 to 300 ?g/ml) , how do You take vitamin B12 supplements? 1 Contains methyl cobalamin , methyl vitamin B12 vitamins to supplement vitamin B12 can be converted into methylcobalamin in the body, methylcobalamin is involved in cell metabolism, if lack, it will lead to the cessation of blood cell division, causing macrocell anemia , even if overdoses are not related, because vitamin B12 is a water-soluble vitamin, and excess vitamin B12 is excreted with urine 2 Food supplements are also supplemented by food, rich in vitamin B12-rich foods such as liver, meat, fish, shellfish, egg yolks, milk, yeast, beans, spinach, potatoes, sunflower seeds, pears, etc take metformin to pay attention to 3 points: 1 When taking, start with a small dose and gradually increase the amount Generally from two times a day, one piece at a time, if you need to increase the amount of medicine, you can increase 1 tablet per week, if there is no obvious discomfort, can be maintained twice a day, two tablets at a time, specific requirements to follow the advice of a professional doctor, under its guidance of medication 2 Patients with insufficiency of liver disease, heart failure, severe infection, having just undergone major surgery, and low blood pressure should be taken with caution During the period of taking the medicine should also be regularly to the hospital blood test, can not stop the medicine or increase the dose 3 Avoid taking the same drug with drugs that may interact with metformin Such as diabetes drugs, thyroid drugs, cholesterol drugs, gastrointestinal drugs, antihypertensive drugs and so on
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